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1、氟比洛芬酯防治丙泊酚注射痛临床探索【摘要】目的观察氟比洛芬酯防治丙泊酚注射液注射痛的效果。方法90例ASAⅠ～Ⅱ级采用丙泊酚注射液诱导全麻病人，随机分成六组，各15例。A组静推氟比洛芬酯5ml(含量50mg)，60min后开始丙泊酚注射液诱导麻醉；B组静推氟比洛芬酯5ml，30min后开始丙泊酚注射液诱导麻醉；C组静推氟比洛芬酯5ml，10min后开始丙泊酚注射液诱导麻醉；D组静推氟比洛芬酯5ml后用压脉带扎于肘部60秒后开始静推丙泊酚注射液麻醉诱导；E组静推氟比洛芬酯60s后开始静推丙泊酚注射液麻醉诱导；F组静推氟比洛芬酯5ml后即刻开始丙泊酚注射液麻醉诱导。结果疼
2、痛发生率及疼痛评分：A组、B组与C组比较差异有显著性（P＜0.05），A组与B组比较差异无显著性（P＞0.05），E组、F组与D组比较差异有显著性（P＜0.05），E组或F组与A组或B组比较差异无显著性（P＞0.05），D组与A、B组比较差异有显著性（P＜0.05）。结论氟比洛芬酯对预防丙泊酚注射液注射痛有效，用药后即刻予丙泊酚注射液时对注射痛预防效果最好。【关键词】氟比洛芬酯丙泊酚注射痛 【Abstract】ObjectiveToobservetheclinicaleffectofusingflurbiprofenaxetilinjectionintreating
3、painonpropofolinjection.Methods90casesofASA1～2gradepatientsunderpropofol-inducedanaesthesiaweredividedrandomlyinto6groupswith15patientsineachgroup.IngroupA,5mlflurbiprofen（50mg）axetilwasintravenousinjected60minbeforepropofol-inducedanaesthesia;ingroupB,5mlflurbiprofenaxetil（50mg）wasintr
4、avenousinjected30minbeforepropofol-inducedanaesthesia;ingroupC,5mlflurbiprofenaxetil（50mg）wasintravenousinjected10minbeforepropofol-inducedanaesthesia;ingroupD,5mlflurbiprofenaxetil（50mg）wasintravenousinjected,thenelbowwaspressedwithbloodpressurecufffor60secbeforepropofol-inducedanaesth
5、esia;ingroupE,5mlflurbiprofenaxetil（50mg）wasintravenousinjected60secbeforepropofol-inducedanaesthesia;ingroupF,propofol-inducedanaesthesiabeganrightaftger5mlflurbiprofenaxetil（50mg）wasintravenousinjected.Theinjectingspeedremainedconstantly（500ml*h-1）.PainofinjectionwasrankedaccordingtoA
6、mbesh'spainscore(none,mild,moderate,andsevere).ResultsInpain'sincidencerateandranking:therewassignificantdifference（P＜0.05）betweengroupAandgroupC,groupBandgroupC,therewasnosignificantdifferencebetweengroupAandgroupB（P＞0.05）,therewassignificantdifference（P＜0.05）betweengroupEandgroupD,gro
7、upFandgroupD,therewasnosignificantdifferencebetweengroupEandFcomparedwithgroupAandgroupB（P＞0.05）,comparedwithgroupAandgroupB,therewassignificantdifferenceingroupD（P＜0.05）.ConclusionItiseffectivetouseflurbiprofenaxetilinjectionintreatingpainonpropofolinjection,besttimefor4propof
