辅酶q10对紫外线致角膜上皮细胞光损伤的保护作用

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1、万方数据国际眼科杂志2009年12月第9卷第12期W、M^，．IJO．cn皇适；Q竺!：璺竺竺箜!Z竺垒!Q堕垒垫皇圣笪煎；些Q：兰QQQ皇!箜：12竺．．·实验论著·辅酶Q1O对紫外线致角膜上皮细胞光损伤的保护作用苟春风1，刘勤2，郝保安1，苏兰萍1，王雅东1作者单位：1(?30000)巾围甘肃省兰卅I市。甘肃省康复中心医院眼科；2(730(X)0)中国11‘肃省兰州市，甘肃省人民I矢院眼科作者简介：苟春风，女，硕上，卡治医师，研究力‘向：眼表疾病。通讯作者：刘勤，主任医师．summliu@126．eo

2、m收稿13期：2009．07．03修回日期：2009—08—10ProtectiveeffectofcoenzymeQIOonultravioletirradiation-inducedinjuryofratscornealepitheliumChun-FengGou。，QinLiu2，Bao-AnHa01，Lan-PingSul，Ya．DongWan91。DepartmentofOphthalmology，theRehabilitationCenterHospitalofGansuProvince，La

3、nzhou730000。GansuProvince，China；2DepartmentofOphthalmology．thePeople'sHospitalofGansuProvince．Ldnzhou7300(J()．GansuProvince．ChinaCorrespondenceto：QinIJu．DepartmentofOphthalmology，thePeople’SHospitalofGansuProvince．IJanzhou730000．GansuProvince．China．summli

4、u@126．cornReceived：2009一07．03Accepted：21309—08．10Abstract·AlM：Toexploretheprotectivee仟ectofcoenzymeQ10onultraviolet(UV)irradiation—inducedinjuryofratscorneaIepitheliumanditsmechanisms．·METHODS：Forty—eightWistarratsweredividedrandomlyintonormalcontrolgroup

5、。positivecontroIgroupandcoenzymeQ10group．TheUVirradiation—induceddamagemodeIofWistarratswasestablishedbyexposingtoultraviolet．TheratsincoenzymeQ10groupwereintragastricadministratedbycoenzymeQ10every—dayforthreeweeksbeforeandduringUVexposure．Theratsinnorma

6、lgroupdidnotreceivedultravioletlight，andtheratsfrompositivegrouponlyunderwentultravioletraywithouttheadministrationofdrug．Histopathologicchangeswereobservedwithlightmicroscopy．ThecontentsofmaIondiaIdehyde(MDA)，superoxidedismutase(SOD)inthecorneaIepitheliu

7、mweremeasuredbyphotometry．StatisticaIanalysiswasusedtoassessresuIts．·RESULTS：AfterUVirradiation．jnducedinjury．thecontentofMDAinpositivecontroIgroupwasincreasedandactivityofSODwasdecresedobviously，whichsignificantlydifferedfrOmthenormalcontrolgroup(P<0．01)

8、．Incontrasttothepositivegroup．thecontentofMDAincoenzymeQ10groupwasreducedandactivityofSODwasincreased(P<0．05)．·CONCLUSION：CoenzymeQ10，byremovingoxygenfreeradicals．elevatingtheabilityofanti—oxidationincorneaIepitheli