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1、ThesiRNAtreatmentforcancerAbstract:SmallinterferingRNA (siRNA),alsoknownas shortinterferingRNA,playsanimportantroleinthe RNAinterference pathway,whereitinterfereswiththe expression ofspecificgeneswithcomplementarynucleotidesequence.Inrecentyears,siRNAhasprovidedapromisingthe
2、rapeuticmodalityforthetreatmentofcancer. Thus,thisarticlewillprovideanoverviewoftheinhibitoryeffectexertedbysiRNAonvariouskindsofcancer.ItalsodescribesthesynergisticeffectofsiRNAandothertherapy.Finally,thedeliverysystemofsiRNAwillbediscussedaswell.Keywords:siRNA,cancer,treat
3、ment,combinedtherapy,deliverysystemIntroduction:SmallinterferingRNA(siRNA)isakindofnon-codingdouble-strandedRNAs21–25nucleotidesinlengthwhichcaneffectivelyinhibitthetranslationoftargetmRNAsbybindingtotheir3′-UTRthroughspecificcleavageofperfectlycomplementarymRNA[1].Thus,siRN
4、Aisonekindofthe RNAinterference (RNAi)pathway.TherehasrecentlybeenanincreasinginterestinharnessingsiRNAtodevelopnoveltreatmentofvariousdiseases,suchascancer,neurologicaldisorders,age-relatedmaculardegenerationandviralinfections[2]. Amongthem,siRNAshavedisplayedconsiderablepr
5、omiseforthetreatmentof cancerbecausesiRNAhasdistinctadvantagesoverconventionalsmallmoleculeorprotein-baseddrugs,includinghighspecificity,higherpotencyandreducedtoxicity[2]. Therefore,thisreviewwillfocusedprimarilyontheresearchesaboutthesiRNAtreatmentfordifferentkindsofcancer
6、.Secondly,areviewofthetherapieswhichcombinesiRNAandconventionalcancerdrugwillbepresentinthisarticle.Moreover,thedeliveryofsiRNAwillbediscussedaswell.siRNAcanbeanoveltreatmentofcancer:NumberousresearcheshavedemonstratedthatsiRNAcouldbeapotentialeffectivetreatmentforcancer.Tab
7、le1hassummarizedtherepressiveeffectofsiRNAtargetingdifferentgenesonvarioussortsofcancer.Fromtable1,wecanseethatsiRNAcaninhibittumorcellviabilityandproliferation.Moreover,siRNAperformsthefunctionofinducingapoptosisandreversingmultidrugresistance.Table1TreatmentofsiRNAfordiffe
8、rentsortsofcanceryearsmortgagehousing;4.mortgageregistrationformalitiesarec
