细胞连接与细胞粘连

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1、第七章细胞连接与细胞粘连Celljunctionandcelladhesion第一节细胞连接celljunction1、封闭连接Occludingjunction2、锚定连接Anchoringjunctions3、通讯连接Communicationjunctions第二节细胞粘附分子celladhesionmolecule1、Occludingjunction(tightjunctions)2、Anchoringjunctions（1）Actinfilamentattachmentsitesa.Cell-celladherensjunctions(adhesionbelts)b.

2、Cell-matrixadherensjunction(focalcontacts)（2）Intermediatefilamentattachmentsites.a.Cell-cell(desmosomes)b.Cell-matrix(hemidesmosomes)3、Communicationjunctions（1）Gapjunctions（2）ChemicalsynapsesThreetypesofCellJunctions:闭锁连接(occludingjunction)：紧密连接(tightjunction)TheTightJunctionFormsBarrierAcros

3、sCellsDespitethemanystructuralandbiochemicaldifferenceamongvarioustypesofepithelia,allhavethefunctionofbeingselectivelypermeabletofluidsoneachside.TheTightjunctionplaytwodistinctrolesinthisselectivebarrierfunction.Preventtheapicalmembraneproteinsfrommovingtobasolateralsurface.Sealthespacesbet

4、weenepithelialcellstopreventsothatmoleculescannotmovebetweencells.desmosome电镜下显示细胞间连接——桥粒通讯连接(communicatingjunction)：是细胞间的一种连接通道，除了使细胞间相互连接外，还介导细胞通讯，包括：（1）间隙连接(gapjunction)；（三）化学突触(chemicalsynapse)：由突触前膜、突出间隙和突触后膜组成，信息的传递需要有传递物（如神经递质）Legend:Whenanactionpotentialreachesanerveterminal,itopensvo

5、ltage-gatedCa2+channelsintheplasmamembrane,allowingCa2+toflowintotheterminal.TheincreasedCa2+inthenerveterminalstimulatesthesynapticvesiclestofusewiththeplasmamembrane,releasingtheirneurotransmitterintothesynapticcleft