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ID:21227449
大小:2.13 MB
页数:19页
时间:2018-10-20
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1、Calix[4]arenesasMolecularPlatformsforMagneticResonanceImaging(MRI)ContrastAgentsThePaperOutlineConclusion3Introduction1ExperimentalSection21、IntroductionMolecularimagingItseemstotakephotosofmolecular,displaythemorphologicalstructureofourtarget.Inotherwords,characterizationandmeasurementofthepr
2、ocessoflivinganimals,humanbiologyandmodelsysteminthecellularandmolecularlevelusingtheimagingdetectorinvitro.FeaturesofmolecularimagingNon-invasiveimagingtechniqueDynamicacquisitionReflectfull-scaleSomemainimagingtechniquesPositronemissiontomography(PET)Singlephotonemissioncomputedtomography(SP
3、ECT)Magneticresonanceimaging(MRI)UltrasonicimagingOpticalimaging(Bioluminescence,Fluorescence)MRIMagneticresonanceimaging(MRI)isoneofthemostimportanttechniquesinmedicalimaging.Itisnoninvasive,avoidsproblemsoccurringinotherimagingtechniquessuchasscattering(opticalimaging)orhigh-energyradiation(
4、computedtomography(CT)orX-ray),andenablestheproductionof3Dimagesofvarioustissues.Thechallengeistopreparecomplexesthatdonotreleasethetoxicmetalioninvivoandyetareefficientcontrastagents.2、ExperimentalSectionThecontrastisgeneratedbydifferencesineithertheprotondensitybetweentissuesand/ordifference
5、sinT1orT2relaxationtimes.Anoncovalentapproachistoprepareamphiphiliccompoundsthatformaggregates.Targetedcontrastagentsusuallyhavehigherrelaxivitieswheninteractingwiththetargetduetotherestrictionoftherotationalmotionuponbinding.InMRIanongoingtrendistoapplyhighermagneticfieldstrengths(>1.5T).This
6、canbeachievedbyoptimizingtheaveragewaterresidencelifetimetMtoevenshortervaluesthanthatpredictedof20–40nsforhighmolecularweightagents.OneofapproachestofindsystemswithoptimalτRistousetheratherrigidcalix[4]arenecoreasasyntheticplatform.Calixarenesgenerallyenabletheintroductionofatleasttwodifferen
7、tfunctions.AggregationVariable-temperature17ONMRmeasurementsWithintheexperimentalerror,thehyperfinecouplingconstantisidenticaltocommonlyobservedvaluesforoxygenatomsdirectlycoordinatedtoGd.NuclearmagneticrelaxationdispersionNMRDisapowerf
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