医学毕业论文hbig阻断乙型肝炎病毒母婴传播

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1、HBIG阻断乙型肝炎病毒母婴传播姓名：2014年6月25日HBIG阻断乙型肝炎病毒母婴传播作者：崔恒春，闫永平，邵中军，徐徳忠，门可，徐剑秋，李军【关键词】乙型肝炎病毒；垂直传播；免疫球蛋白类EffectofHBIGonblockingmothertoinfanttransmissionofHBV【Abstract】AIM:ToevaluatetheblockingeffectofhepatitisBimmunoglobulin(HBIG)administratedtoHBsAgpositivepregnantwomenduringlatepregnancyandimmunere

2、agents(HBIGtogetherwithHBVvaccine)totheirneonatesonmothertoinfanttransmissionofHBVanditschronicity.METHODS:Eachinfantinthehistoricalcontrolgroup(n=205)wasonlyimmunizedwith3dosesofplasmaderivedvaccineroutinely,whileeachpregnantwomanintheHBIGgroup(n=213)wasgiven200uHBIGintramuscularlyevery4week

3、sfrom28thweekofgestationandeachoftheirinfantswasinjectedintramuscularlywithHBIG200uatbirthand15dafterbirthandthenwith3dosesofrecombinantyeastderivedhepatitisBvaccineroutinely.AllinfantswerefolloweduptoobservethechangeofserumHBsAg.Ahistoricalcontrolclinicaltrialwasperformedtoevaluatetheblockin

4、geffectofHBIGinjectedtomothersandtheirnewbornsonmothertoinfantHBVtransmissionanditschronicity.RESULTS:TheratesofintrauterineHBVinfection,seroconversiontoHBsAgpositivityininfantsduringfollowup，HBVinfectionchronicitywere5.34%,5.15%,87.5%respectivelyincontrolgroup,and5.26%,0,18.18%respectivelyin

5、HBIGgroup.TherateofintrauterineHBVinfectionwasnosignificantlylowerinHBIGgroupcomparedwiththatincontrolgroup(P=1.000).ThereweresignificantdifferencesfortherateofseroconversiontoHBsAgpositivityduringfollowupandHBVinfectionchronicity(P=0.019，0.001respectively).CONCLUSION:HBIGadministratedtoHBsAg

6、positivepregnantwomenduringlatepregnancycantpreventintrauterinetransmissionofHBVeffectively.HBIGtomothersandtheirneonatescanimprovetheblockingeffectofHBVvaccineeffectivelyontheseroconversiontoHBsAgpositivityduringfollowupandHBVinfectionchronicityininfants.【Keywords】hepatitisBvirus；verticaltra

7、nsmission；immunoglobulins【摘要】0的：评价HBsAg阳性母亲孕晚期肌注HBIG（乙肝免疫球蛋白）及婴儿出生后HBIG联合乙肝疫苗对HBV母婴传播及慢性化阻断的效果.方法：历史对照组只对婴儿进行乙肝疫苗的全程免疫；HBIG组母亲孕晚期3nw每月肌注200u的HBIG;婴儿出生时、半月龄时分别肌注200u的HBIG,并常规接种乙肝疫苗.随访两组婴儿HBsAg变化情况，采用历史对照临床试验评价母亲及新生儿注射HBIG对HBV母婴传播及慢性化的阻断效果.结果：历