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《黄连温胆汤加味对葡萄糖调节受损患者的临床干预研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、提要目的：观察分析以清热祛湿，化痰活血为治则的黄连温胆汤加味结合生活方式治疗对糖调节受损患者（IGR）的临床干预疗效，并探讨其作用机理。方法：采用随机、对照的方法，将60例患者分为治疗组（30例）和对照组（30例）。对照组只接受生活方式的治疗，治疗组在其基础上加用黄连温胆汤加味，观察时间为3个月，主要观察指标：临床症状、血糖、血脂、糖化血红蛋白、胰岛素水平、体重指数、腰臀比等。结果：治疗组干预后空腹及餐后血糖、血脂、糖化血红蛋白、胰岛素水平、体重指数、腰臀比、临床症状积分等较前有明显改善，与对照组比较有显著性差异。
2、试验期间未发现不良反应。一年后随访治疗组糖尿病转化率低于对照组。结论：黄连温胆汤加味法联合生活方式干预对IGR患者疗效显著，可以降糖、调脂；降低体重指数及腰臀比水平，改善胰岛素抵抗；能明显改善IGR患者的临床症状，较好地逆转IGR及延缓IGR向糖尿病的转化，且用药安全，证明了中医药辨证论治糖调节受损具有很广阔的前景。关键词临床研究；糖调节受损；清热祛湿、化痰活血法；黄连温胆汤加味TheClinicalInterventionStudyofHerbalMedicineHuangLianWenDanTangonsubj
3、ectswithImpairedGlucoseRegulationSpecialty:InternalMedicineofTraditionalChineseMedicineAuthor:YuMiaoTutor:Prof.XuYunshengAbstractObjective:StudytheclinicalcurativeeffectofChinesepatentdrug“HuangLianWenDanTang”usingthemethodofQingrequshiexpectoranthuatanhuoxuem
4、ethodwithcombinedtherapyofsexwayonpatientswithIGRanddiscusstheinterventionmechanism.Methods:Takingthemethodofrandomized,placebocontrolledprospectiveparallel,60patientswithIGRwererandomlydividedintotreatmentgroup(n=30)andthecontrolgroup(n=30).Treatmentgrouprece
5、ivedbehaviorinterventionplusHuangLianWenDanTangtreatment,andthecontrolgroupreceivedbehaviorinterventionplusplacebotreatment.Observationtimelastfor3months,themainoutcomemeasuresareasfollows:theclinicalsymptoms,thebloodsugar,bloodfatandglycatedhemoglobin,insulin
6、levels,bodymassindex,waist-hipratios,etc.Results:Thebloodsugar,bloodfatandglycatedhemoglobin,insulinlevels,bodymassindex,waist-hipratios,clinicalsymptomofthetreatmentgroupwereobviouslyimproved,whichshowedsignificantdifferencefromthecontrolgroup.Duringthetestsa
7、dversereactionsdidnotappear.Andinayearlater’sfollow-up,diabetesconversionrateofthetreatmentgroupislowerthanthoseofthecontrolgroup.Conclusion:ThecompoundmethodofQingrequshiexpectoranthuatanhuoxuemethodcombinedwithbehaviorinterventionhascurativeeffectonIGRpatien
8、ts:decreaselipidsugar,reduceweightindexandwaist-hipratios,improvetheinsulinresistance;theclinicalsymptomsofIGRcanbeobviouslyimproved,thedrugcanbesafelyusedanditmayreverseIGRanddela
