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ID:33762263
大小:3.78 MB
页数:52页
时间:2019-03-01
《aktmtor信号传导通路在胃癌组织中的表达及意义》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、泰山医学院硕士学位论文Akt/mTOR信号传导通路在胃癌组织中的表达及意义姓名:辛利申请学位级别:硕士专业:内科学指导教师:王庆才2012-03Akt/mToR信号传导通路在胃癌组织中的表达及意义研究生:辛利专业:消化内科导师:王庆才教授中文摘要目的通过检测脂、mTOR在胃癌组织、癌旁组织中的表达,分析地、mTOR的表达水平与胃癌临床病理特征的关系,为胃癌的预后提供参考,为临床寻找治疗恶性肿瘤的新靶点提供依据。材料与方法收集泰安市中心医院2011年6月~2012年1月问手术切除并经病理证实、资料完整的胃癌组织
2、32例,癌旁组织标本20例,应用免疫组化染色测定p-m口和p.mTOR在胃癌、癌旁中的表达情况,并分析其与常见临床病理因素之间的关系。结果p—AKT在胃癌、癌旁组织中的阳性表达分别为71.9%、25%;p—mTOR在胃癌、癌旁组织中的阳性表达分别为62.5%、20%。胃癌组织中p一越汀、p—InTOR的表达较癌旁组织明显升高(p3、者T、N、M分期存在相关性0<0.05)p一脚订、p—InTOR的表达与胃癌患者的年龄、性别、肿瘤直径大小无相关性(p>0.05)。结论AKT/mTOR信号通路的过度表达在胃癌、癌旁组织中呈递减的趋势;胃腺癌组织中p.触与p.mTOR蛋白的表达呈正相关;此通路在胃癌组织中的表达与病理分化程度呈负相关性。AKT/mTOR信号通路在大部分胃癌组织中过度表达可能是胃癌发生发展的重要机制之一。关键词AKT;mTOR;胃癌:免疫组织化学TH噩EXPRESSIONANDSIGNIFICANCEOFTHEAKT/mToRS4、IGNALINGPATII、ⅣAYINGASTIUCCARCINoMAobjectivePostgraduate:ⅪnLiSpeciali哆:DepartmentofGastroenteroIogyTutor:ProfessorWangQingcaiABSTRACTThepu印oseofstIldyistoexploretheexpressionofAKT、mTOR(ProteinbnaseB、mammaliantargetofr叩锄ycin)ingastriccancerandparacallcertiss5、ues.Byanalysisoft11erelationsllipsofAKT、mTORa11dclillicalpathologiccharacteristicofgaStriccancer,topr01I,idet11eref-erencefortheclillicalindividuationmedicationalldⅡ:Leprognosisjudgement.MaterialsandMethods’I'lleexpressionofp—AKTa11dp—mTORweredetectedin32st6、omachcarcillomatollStissuesaIld20paracancertissuesbyimmuIlollistoche蚵shySPmemod.Alloftissueswerecollected丘.omsur西calproceduresiIlTaiaIlCe砷试HoSpital6.0mJune2011toJanua巧2012,wbjchwerecon丘肌edbypaⅡ10logyaIldthedatawaLsirItact,anda11alysisoftllerelationsmpwimthe7、commonclinicalandpatllologicalf-aCtorS.ResultsThepositiveexpressionofp—AKTingaStriccarcinomaaIldparaCaIlcertissues、vaS71.9%,25%;ThepositiVeeXpressionofp—mTORiIlgaLstricc鄱cillomaa11dparacaIlcertissueswaS62.5%,20%;111eexpressionofp。AKT孤dp_mTORiIlgaStriccancer8、tissuesweresi嘶6c趾tlyinCreaSe—dcomparedtopamcallcertissues0<0.05);Theexpressionofp—AKTaIldp—mTORingaStriccaIlcer、vererelatedtomedif.f-erent.tiateddegreesoflliStologicaltissues0<0.05),thesi嘶ficantexpress
3、者T、N、M分期存在相关性0<0.05)p一脚订、p—InTOR的表达与胃癌患者的年龄、性别、肿瘤直径大小无相关性(p>0.05)。结论AKT/mTOR信号通路的过度表达在胃癌、癌旁组织中呈递减的趋势;胃腺癌组织中p.触与p.mTOR蛋白的表达呈正相关;此通路在胃癌组织中的表达与病理分化程度呈负相关性。AKT/mTOR信号通路在大部分胃癌组织中过度表达可能是胃癌发生发展的重要机制之一。关键词AKT;mTOR;胃癌:免疫组织化学TH噩EXPRESSIONANDSIGNIFICANCEOFTHEAKT/mToRS
4、IGNALINGPATII、ⅣAYINGASTIUCCARCINoMAobjectivePostgraduate:ⅪnLiSpeciali哆:DepartmentofGastroenteroIogyTutor:ProfessorWangQingcaiABSTRACTThepu印oseofstIldyistoexploretheexpressionofAKT、mTOR(ProteinbnaseB、mammaliantargetofr叩锄ycin)ingastriccancerandparacallcertiss
5、ues.Byanalysisoft11erelationsllipsofAKT、mTORa11dclillicalpathologiccharacteristicofgaStriccancer,topr01I,idet11eref-erencefortheclillicalindividuationmedicationalldⅡ:Leprognosisjudgement.MaterialsandMethods’I'lleexpressionofp—AKTa11dp—mTORweredetectedin32st
6、omachcarcillomatollStissuesaIld20paracancertissuesbyimmuIlollistoche蚵shySPmemod.Alloftissueswerecollected丘.omsur西calproceduresiIlTaiaIlCe砷试HoSpital6.0mJune2011toJanua巧2012,wbjchwerecon丘肌edbypaⅡ10logyaIldthedatawaLsirItact,anda11alysisoftllerelationsmpwimthe
7、commonclinicalandpatllologicalf-aCtorS.ResultsThepositiveexpressionofp—AKTingaStriccarcinomaaIldparaCaIlcertissues、vaS71.9%,25%;ThepositiVeeXpressionofp—mTORiIlgaLstricc鄱cillomaa11dparacaIlcertissueswaS62.5%,20%;111eexpressionofp。AKT孤dp_mTORiIlgaStriccancer
8、tissuesweresi嘶6c趾tlyinCreaSe—dcomparedtopamcallcertissues0<0.05);Theexpressionofp—AKTaIldp—mTORingaStriccaIlcer、vererelatedtomedif.f-erent.tiateddegreesoflliStologicaltissues0<0.05),thesi嘶ficantexpress
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