固本祛瘀,化痰调脂法治疗老年高脂血症的临床观察

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1、提要目的：观察固本祛瘀，化痰调脂法治疗老年高脂血症的临床疗效，并探讨其作用机理。方法：采用随机双盲分组的方法，将符合纳入标准的60例老年高脂血症患者分为治疗组和对照组两组，每组各30人。治疗组采用固本调脂汤加辛伐他汀10mg治疗；对照组采用辛伐他汀20mg治疗。8周为一个疗程。治疗前后检测患者血清总胆固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白、载脂蛋白水平，动脉硬化指数（AI），血流变学指标及患者中医症候变化情况。结果：治疗组症状改善总有效率为93.33%，显效率为53.33%，与对照组相比较有显著性差异(P<0.05)；治疗组TC、LDL-C、TG、ApoB明显降低，HDL-C、A

2、poA1明显升高，与对照组无差异(P>0.05）。治疗组Lp(a)明显降低，与对照组比较有显著性差异(P<0.05或0.01)。两组治疗后动脉硬化指数（AI）与血液流变学变化治疗组均优于对照组，有显著差异（P<0.05）。结论：固本祛瘀，化痰调脂法是治疗老年高脂血症的一种有效方法，并具有改善血流动力学变化、动脉硬化指数水平以及患者临床症状的作用。关键词老年高脂血症；固本祛瘀化痰调脂；临床研究ClinicalResearchonTreatmentofHyperlipidemiaUsingthewayofsupportinghealthyenergy,eliminatingstasis,

3、alleviatingphlegmandregulatinglipidSpeciality：InternalMedicineofTraditionalChineseMedicineAuthor：WangZhilinTutor：Prof.BaoPeirongAbstractObjective:toobservetheclinicalcurativeeffectoftreatingsenilehyperlipidemiainthewayofsupportingenergy,eliminatingstasis,alleviatingphlegmandregulatinglipid,then

4、researchonthemechanismofthemethod.Methods:groupingdoubleblindly,sixtycasesofsenilehyperlipidemiaaredevidedintotwotreatmentgroup,30personeachgroup.Thetreatmentgroupwastreatedwithhealthyenergysupportingsoupand10mgsimvastatin,thecontrolgroupwastreatedwith20mgsimvastatin.Atreatmentperiodlastfor8wee

5、ks.Checkthefollowingindexofpatientsbeforeandafterthetreatment:triglycerides,high-densitylipoproteincholesterol(hdl-c),lowdensitylipoprotein,apolipoproteinlevel,arteriosclerosisindex(AI),hemorrheologyindexandsymptom.Results:effectiverateoftreatmentgroupwhosesymptomwereimprovedwas93.33%,ofwhich53

6、.33%significantly.Comparedwiththecontrolgroup,theTC,LDL-C,TG,ApoBwerereducedsignificantly.hdl-c,ApoA1wereincreasedsignificantly,thesamewiththecontrolgroup.(P>0.05).Lp(a)wasreducedsignificantlyinthetreatmentgroup,withsignificantdifferencecomparingtocontrolgroup.atherosclerosisindex(AI)andthehemo

7、rrheologicintreatmentgroupwerebothbetterthanthecontrolgroup,withnotabledifference(P<0.05).Conclusion:supportingenergy,eliminatingstasis,alleviatingphlegmandregulatinglipidmethodisakindofeffectivemethodontreatingsenilehyperlipidemi