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1、irradiationwithmedicallinearaccelaratorin6MVXray.Eachgroupweregiven0、0.5、1、2、3、4、6、8、10Gyofirradiationdose.Thedoseratewas412.31cGy/min,SSD=100cm,PDD=97.232%,theirradiationareawas30×30cm.Freshmediumwasreplacedinfourhoursafterirradiation,theCNE-2cellsculturedinthe
2、incubatorat37°C,0.5%CO2thermostatfor14d,recordsthekillingeffectofdifferenttreatments,calculatethesurvivalrate,cloneformationratewithapplicationofcountingcolony-formingmethod;themathematicalmodelofthesingle-hitmulti-targetwasusedtoplotsurvivalcurve(theGraphPadPri
3、sm5.0software).CalculateN,D0,Dq,SERD0,SERDq,SERSF2,comparethedifferenceofirradiationalonegroupanddrug+radiationgroup,aswellasdifferentdrugs+irradiationsubgroup.Results：TheIC10ofCisplatin,Carboplatin,OxaliplatinandNedaplatinonCNE-2were0.28ug/mland1.201527ug/ml1.4
4、3ug/mland6.301118ug/mlrespectively,theIC50were18.78ug/mland1.56808ug/mlrespectively.TheplatingefficiencyofCNE-2was72%.ThevalueofN,D0andDqofCNE-2cellsreceivedtreatmentofradiationalonewere2.305,1.478Gy，1.234Gyrespectively;thevalueofN,D0,DqSERD0、SERDqandSERSF2ofCNE
5、-2cellsreceivedCisplatin+radiationwere2.547,1.011Gy，0.945Gy,1.462,1.678,1.579respectively;thoseofCNE-2cellsreceivedCarboplatin+radiationwere2.263,0.994Gy,0.812Gy,1.487,1.521,1.796respectively;thoseofCNE-2cellsreceivedOxaliplatin+radiationwere1.306,0.969Gy,0.789G
6、y,1.524,1.563,1.884respectively;Nedaplatin+radiationwere2.098,0.954Gy,0.707Gy,1.549,1.745,2.070respectively.Conclusions：Cisplatin,Carboplatin,OxaliplatinandNedaplatinhaveshowntheradiosensitizingeffectinvitroonNasopharygealCarcinomaCNE-2humannasopharygealcarcinom
7、acelllinerespectively,Ontheconditonofthesamecellcytotoxicity,Nedaplatinhasthemostradiosensitioneffect,thenextisOxaliplatinandCarboplatin.TheCisplatinwastheworst.KeyWords:Cisplatin/Carboplatin/Oxaliplatin/Nedaplatin/platinumcompounds/NasopharygealCarcinomaCellLin
8、e前言鼻咽癌是鼻咽部上皮组织发生的恶性肿瘤,是中国南部及东南亚地区[1-2]最常见的恶性肿瘤之一,具有很高的发病率，世界卫生组织（WHO）所做统计调查发现，全世界大约80%的鼻咽癌都发生在中国，尤以华南地区为最，呈现高发状态，而广东地区的发生率又居全国之首。大约每10000人就有1.5一5个人发病，故又被称为―广东癌‖。鼻咽癌占全
