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ID:33994384
大小:1.91 MB
页数:51页
时间:2019-03-03
《益气养阴法治疗iga肾病气阴两虚型的疗效观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、成都中医药大学硕士学位论文学位论文指导教师姓名:餐惠荃圭堡匡』匝申请学位级别:亟±堂僮专业名称:生酉匡结金监鏖论文提交时间:垄Q呈2生垒目论文答辩时间:垄Q!垄生量且二O一二年四月成都中医药大学硕士学位论文中文摘要目的:本研究通过观察益气养阴法对气阴两虚型IgA肾病(IgA,nephropathy,IgAN)的临床总疗效、中医证候总积分、24h尿蛋白定量、尿沉渣镜检红细胞计数、平均动脉压、肾功能(肌酐、尿素氮)、内生肌酐清除率、血清免疫球蛋白(IgA)、补体C。及IgA/C。值等实验室指标水平的影响,从而客观评价益气养阴法对气阴两
2、虚型IgAN的临床疗效及预后,并进一步探讨其作用机制。方法:将肾穿刺确诊为IgAN的52侈,J患者按就诊顺序随机均分为治疗组和对照组,对照组给予单纯西药治疗,治疗组在对照组基础上加服益气养阴方(四川省中医院/成都中医药大学附属医院舒惠荃教授经验方)加减治疗,3个月为一疗程,两组均治疗~个疗程。观察两组患者治疗前后中医证候积分及各实验室指标水平的变化情况,并对比其疗效。结果:(1)两组临床总疗效比较:治疗组总有效率为88.5%,对照组为69.2%,两组比较有显著性差异(P3、2.3%,对照组为73.1%,两组比较有显著性差异(P0.05),治疗后治疗组总积分较对照组显著下降,两组比较有显著性差异(P4、及IgA/C。下降水平优于对照组,两组比较有显著性差异(P5、influenceofYIQIYANGYIN(YQYYF)onIgA—nephropathyofbothQiandYinDeficiencytype,tocalendarthetotalcliniceffects,thegeneralintegralofTCMsymptoms,proteinuriaexcretionof24hours,urineredbloodcellscount,meanarterypressure,renalfunction(BUN,Scr),creatinineclearance(Ccr),serumimm6、unoglobulin(IgA),complementC3,IgA/C3andSOon.MeanwhiletrytoassessobjectivelythecliniceffectsandprognosisofYIQIYANGYINDecoctiononIgANofQiandYinDeficiencytype,andtofurtherstudythemechanisms.Methods:52patientsdiagnosedofIgANwererandomlydividedintotreatmentgroupandcontrast7、group.ThecontrastgroupweretakenwithWesternmedicinealone.PatientsoftreatmentgroupweregivendailytheYIQIYANGYINDecoctionthetreatmentofcontrastgroup.Bothgroupsweretreatedforthreemonthasonecourse,ObservethechangeofgeneralintegralofTCMsymptomsandotherlaboratoryparametersbef8、oreandaftertreatment,theeffectsofbothgroupswerecomparedaftertherapy.Results:(1)Comparedwithtotalcliniceffects:inthetreatment
3、2.3%,对照组为73.1%,两组比较有显著性差异(P0.05),治疗后治疗组总积分较对照组显著下降,两组比较有显著性差异(P4、及IgA/C。下降水平优于对照组,两组比较有显著性差异(P5、influenceofYIQIYANGYIN(YQYYF)onIgA—nephropathyofbothQiandYinDeficiencytype,tocalendarthetotalcliniceffects,thegeneralintegralofTCMsymptoms,proteinuriaexcretionof24hours,urineredbloodcellscount,meanarterypressure,renalfunction(BUN,Scr),creatinineclearance(Ccr),serumimm6、unoglobulin(IgA),complementC3,IgA/C3andSOon.MeanwhiletrytoassessobjectivelythecliniceffectsandprognosisofYIQIYANGYINDecoctiononIgANofQiandYinDeficiencytype,andtofurtherstudythemechanisms.Methods:52patientsdiagnosedofIgANwererandomlydividedintotreatmentgroupandcontrast7、group.ThecontrastgroupweretakenwithWesternmedicinealone.PatientsoftreatmentgroupweregivendailytheYIQIYANGYINDecoctionthetreatmentofcontrastgroup.Bothgroupsweretreatedforthreemonthasonecourse,ObservethechangeofgeneralintegralofTCMsymptomsandotherlaboratoryparametersbef8、oreandaftertreatment,theeffectsofbothgroupswerecomparedaftertherapy.Results:(1)Comparedwithtotalcliniceffects:inthetreatment
4、及IgA/C。下降水平优于对照组,两组比较有显著性差异(P5、influenceofYIQIYANGYIN(YQYYF)onIgA—nephropathyofbothQiandYinDeficiencytype,tocalendarthetotalcliniceffects,thegeneralintegralofTCMsymptoms,proteinuriaexcretionof24hours,urineredbloodcellscount,meanarterypressure,renalfunction(BUN,Scr),creatinineclearance(Ccr),serumimm6、unoglobulin(IgA),complementC3,IgA/C3andSOon.MeanwhiletrytoassessobjectivelythecliniceffectsandprognosisofYIQIYANGYINDecoctiononIgANofQiandYinDeficiencytype,andtofurtherstudythemechanisms.Methods:52patientsdiagnosedofIgANwererandomlydividedintotreatmentgroupandcontrast7、group.ThecontrastgroupweretakenwithWesternmedicinealone.PatientsoftreatmentgroupweregivendailytheYIQIYANGYINDecoctionthetreatmentofcontrastgroup.Bothgroupsweretreatedforthreemonthasonecourse,ObservethechangeofgeneralintegralofTCMsymptomsandotherlaboratoryparametersbef8、oreandaftertreatment,theeffectsofbothgroupswerecomparedaftertherapy.Results:(1)Comparedwithtotalcliniceffects:inthetreatment
5、influenceofYIQIYANGYIN(YQYYF)onIgA—nephropathyofbothQiandYinDeficiencytype,tocalendarthetotalcliniceffects,thegeneralintegralofTCMsymptoms,proteinuriaexcretionof24hours,urineredbloodcellscount,meanarterypressure,renalfunction(BUN,Scr),creatinineclearance(Ccr),serumimm
6、unoglobulin(IgA),complementC3,IgA/C3andSOon.MeanwhiletrytoassessobjectivelythecliniceffectsandprognosisofYIQIYANGYINDecoctiononIgANofQiandYinDeficiencytype,andtofurtherstudythemechanisms.Methods:52patientsdiagnosedofIgANwererandomlydividedintotreatmentgroupandcontrast
7、group.ThecontrastgroupweretakenwithWesternmedicinealone.PatientsoftreatmentgroupweregivendailytheYIQIYANGYINDecoctionthetreatmentofcontrastgroup.Bothgroupsweretreatedforthreemonthasonecourse,ObservethechangeofgeneralintegralofTCMsymptomsandotherlaboratoryparametersbef
8、oreandaftertreatment,theeffectsofbothgroupswerecomparedaftertherapy.Results:(1)Comparedwithtotalcliniceffects:inthetreatment
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