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1、BiologyofBloodandMarrowTransplantation13:1016-1021(2007)2007AmericanSocietyforBloodandMarrowTransplantation1083-8791/07/1309-0001$32.00/0doi:10.1016/j.bbmt.2007.05.006UseofFluid-Ventilated,Gas-PermeableScleralLensforManagementofSevereKeratoconjunctivitisSiccaSecondarytoChronicGraft-ver
2、sus-HostDisease12341,3KikuchiTakahide,PabloM.Parker,MichaelWu,WilliamY.K.Hwang,PaulA.Carpenter,121,352CarinaMoravec,BarbaraStehr,PaulJ.Martin,PerryRosenthal,StephenJ.Forman,1,3MaryE.D.Flowers12FredHutchinsonCancerResearchCenter,HematologyandHematopoieticCellTransplantation,CityofHope34N
3、ationalMedicalCenter,UniversityofWashington,Seattle,Washington;SingaporeGeneralHospital,5SingHealth,Singapore;andHarvardMedicalSchoolandBostonFoundationforSight,Boston,MassachusettsCorrespondenceandreprintrequests:MaryE.D.Flowers,MD,ClinicalResearchDivision,FredHutchinsonCancerResearchC
4、enter,1100FairviewAvenueN,D5-290,Seattle,WA98109(e-mail:mflowers@fhcrc.org).ReceivedMarch21,2007;acceptedMay7,2007ABSTRACTKeratoconjunctivitissicca(KCS)occursin40%-60%ofpatientswithchronicgraft-versus-host-disease(cGVHD)afterallogeneichematopoieticcelltransplantation.Althoughimmunosuppre
5、ssivetherapyistheprimarytreatmentofchronicGVHD,ocularsymptomsrequiremeasurestoimproveocularlubrication,decreaseinflammation,andmaintainmucosalintegrity.Theliquidcornealbandageprovidedbyafluid-ventilated,gas-permeablesclerallens(SL)hasbeeneffectiveinmitigatingsymptomsandresurfacingcorneale
6、rosionsinpatientswithKCSrelatedtocausesotherthancGVHD.Wereportoutcomesin9consecutivepatientsreferredforSLfittingforcGVHD-relatedsevereKCSthatwasrefractorytostandardtreatments.AllpatientsreportedimprovementofocularsymptomsandreducedtheuseoftopicallubricantsafterSLfittingresultingfromdecrea
7、sedevaporation.NoseriousadverseeventsorinfectionsattributabletotheSLoccurred.ThemedianOcularSurfaceDiseaseIndeximprovedfrom81(75-100)to21(6-52)within2weeksafterSLfitting,andwas12(2-53)atthetimeoflastcontact,1-23months(median,8.0)afterSLfitting.DisabilityrelatedtoKCSresolvedin7pat
