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1、•基础研究・南方医科大学南方医院肿瘤科，广东广州510515DepartmentofOncolog),NanfangHospital.SouthernMedicalUniversity,(；uangzhou,Guangdong,510515,P.R.China通讯作者：罗荣城Correspondenceto：LLORong-ChengTel：86-20-61641651E-mail:lrc@nnioc.com收稿日期：2006-08-14修回日期：2006-10-30儿丁糖.透明质酸嗨治疗多西紫杉醇外渗性大鼠皮肤损伤朱其聪，李爱民，罗荣城，梁卫江，戴明，陈晓华EfficacyofChitos
2、anandHyaluronidaseonSkinDamageCausedbyDocetaxelExtravasationinRatsZHUQi-Cong,LIAi-Ming,LUORong-Cheng,LIANGWei-Jiang,DAIMing,CHENXiao-Hua[ABSTRACT]BACKGROUND&OBJECTIVE：Docetaxelextravasatingintothesurroundingtissuesmayleadtosevereskindamage・Noguidelineforhandlingdocetaxelextravasationhasbeenproposed
3、tillnow.Thisstudywastoexploretheefficacyofchitosanandhyaluronidaseonskindamagecausedbydocetaxelextravasationinaratmodel.METHODS：Adocetaxelextravasationmodelwasestablishedinbothlowerextremitiesof30Sprague-Dawleyrats.Theratsweredividedinto6groupsandreceivedchitosanembrocation,hyaluronidaseinjection,h
4、yaluronidaseinjectionpluschitosanembrocation,salineembrocation,orsalineinjection,orreceivednotreatmentascontrol.Theoccurreneerateandextentofskindamage,andthehealingtimewereobservedandcompared.RESULTS：Theoccurreneerateofskindamagewassignificantlylowerinhyaluronidasegroupandhyaluronidasepluschitosang
5、roupthaninchitosangroup,salineembrocationgroup,salineinjectiongroup,andcontrolgroup(30%and20%vs.90%,100%,90%and100%,Pv0.05)・Thehealingtimewassignificantlyshorterinhyaluronidasegroupandhyaluronidasepluschitosangroupthaninchitosangroup,salineembrocationgroup,salineinjectiongroup,andcontrolgroup[(12.0
6、0±3.00)daysand(9.50±2.12)daysvs.(18.33±2.00)days,(23.70±2.41)days,(18.44±2.01)daysand(25.70±2.26)days,Pv0・01],andwassignificantlyshorterinchitosangroupthaninsalineembrocationgroupandcontrolgroup(Pv0.01)・CONCLUSIONS：Hyaluronidasealoneorhyaluronidasepluschitosancoulddecreasetheoccurreneerateofskindam
7、agecausedbydocetaxelextravasationinrats,andshortenthehealingtime.Chitosanembrocationcanimprovethedamagehealing,butcan'tdecreasetheoccurreneerateofskindamage・KEYWORDS：Chitosan/treatment；Hyaluronidase/treatme
