资源描述：
《氯吡格雷治疗急性心肌梗死的临床观察》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、氯毗格雷治疗急性心肌梗死的临床观察［摘耍］冃的：探讨氯毗格雷治疗急性心肌梗死(AMI)的有效性和安全性。方法：选择符合溶栓治疗适应证、无溶栓治疗禁忌证发病12h以内的急性心肌梗死患者107例，将其分为观察组和对照组。对照组44例，给了肠溶阿司匹林片口服，丿求激酶静脉溶栓治疗，溶栓12h后皮下注射低分子肝素钙；观察组63例，在对照组治疗基础上加用氯毗格雷负荷量300mg,以后75mg/d0对两组间血管再通率、冠状动脉内血栓形成率和治疗后心肌梗死再发率、出血率、病死率及梗死后心绞痛发牛率等进行比较分析。结果：患者经治疗后心绞痛发牛率、再发心肌梗死
2、率、血管再通率、冠脉内血栓形成率观察组显著低于对照纟fl,差异有统计学意义(PV0.05),心力衰竭率、出血率、脑梗死发生率、死亡率观察组与对照组相比差异无统让学意义(P>0.05)。结论：氯毗格雷治疗急性心肌梗死是安全有效的。［关键词］氯毗格雷；心肌梗死；临床观察［中图分类号］R541［文献标识码］B［文章编号11673-7210(2011)07(c)-146-02ClinicalobservationontreatmentofacutemyocardialinfarctionbyClopidogrelHUANGZhutong,PANXue
3、song,HANFuhaiTheFirstPeople'sHospitalofFangchenggangCityinGuangxiZhuangAutonomousRegion,Fangchenggang538001,China［Abstract］Objective:Toevaluatetheeffectivencssandsafetyofthetreatmentofacutemyocardialinfarction(AMI)withclopidogre1・Methods:107patients(68malesand39females,with
4、AMTwithin12hours)withoutcontraindicationforthrombolytictherapyweredividedintotwogroups:observationgroup(n二44)andcontrolgroup(n=63).ThepatientsoftwogroupsallacceptedentericoralAspirin,intravenousthrombolytictherap・withUrokinaseandsubcutaneousinjectionwith1owmo1ecu1ar~weighth
5、eparincalciumafterthrombolytictherapy12hlater,andtheobservationgroupadded300mgClopidogreland75mgoncedai1yafterthefirstday.Therateofpatencyofinfarct-relatedanery(1RA),intracoronarythrombus,re-infarctionaftertherapy,hemorrhagiccomplications,mortalityandpost-infarctionanginawe
6、recomparedandanalyzedbetweenthetwogroups・Results:Therateofangina,re-infarction,patencyofinfarct-relatedanery(TRA)andintracoronarythrombusinobservationgroupwereobviously1owerthanthoseincontrolgroup(P<0・05).Therewasnosignificantdifferenceintherateofheartfailure,hemorrhagiccom
7、plications,cerebralinfarction,andmortalityinbothgroups(P>0.05)・Conelusion:Thetreatmcntofacutemyocardialinfarctionwithclopidogrelissafeandeffective.［Keywords］Clopidogrel;Myocardialinfarction;Clinicalobservation急性心肌楝死(AMI)发病急骤、凶险，发病24h内病死率较高，已成为发达国家和发展屮国家人口死亡的最常见原因z—,并成为严重的公共
8、卫住问题。其发生的主要的病理牛理机制是动脉粥样硬化斑块破裂，凝血系统被激活而形成血栓。及早行溶栓治疗，恢复梗死区缺血心肌再灌注，能冇效地保护心功能和降低病死率，已成
