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1、热疗联介化疗治疗晩期胃癌的疗效观察［摘耍］冃的观察比较热疗联合全身化疗和单纯全身化疗治疗晚期胃癌的疗效、毒副反M和临床受益率。方法选择51例晚期胃癌患者,其屮热化疗组27例,单纯化疗纟H24例,均采用奥沙利钳联合亚叶酸钙和氟尿喘I定方案化疗。热化疗组使用(13.56±0.2)MHz体外高频热疗机同步进行局部热疗，每周2次。结果热化疗组有效率45%,单纯化疗组为37.5%,两组有效率差界无统计学意义(P〉0.05);热化疗组临床受益率为66%,而单纯化疗组为46.5%,两组临床受益率差界有统计学意义(P<0.05)
2、o两纽患者治疗前后KPS评分的比较差异有统计7意义(P<0.05),两组毒副作用无明显弟异。结论热疗联合全身化疗治疗晩期胃癌具有良好的耐受性和较好的近期疗效。［关键词］胃癌；热疗；奥沙利舘；抗肿瘤联合化疗方案；自身耐受性［中图分类号］R735.2［文献标识码］A［文章编号］1673-9701(2010)09-101-03EfficacyofHyperthermiaCombinedwithChemotherapyinPationtswithAdvaneedGastricCancerGUOJianfengZHANGC
3、unliangZHANGXiangmiaoWANGSueDepartmentofOncology,TheThirdPeople'sHospitalofLuoyang,Luoyang471002,China［Abstract］ObjectiveToobservetheclinicalefficacy,sideeffects,andclinicalbenefitresponseinducedbysystemicchemotherapyplushyperthermiaorsystemicchemotherapyinpa
4、tientswithadvancedgastriccancer.MethodsAtotalof60patientswithadvancedgastriccancerwererecruitedwith32casesinsystemicchemotherapyplushyperthermiagroupand28casesinsystemicchemotherapygroup.ThepatientsinthetwogroupsreceivedL-OHP+LV+5-FUregimens・Inaddition,thepat
5、ientsinsystemicchemotherapyplushyperthermiagroupreceived1ocalhyperthermiatherapyat(13.56±0・2)MHztwiceaweek.ResultsTheresponserateinsystemicchemotherapyplushyperthermiagroupwas45%and37・5%insystemicchemotherapygroup.Thedeffereneowasnotsignificant(P>0.05)・Thecli
6、nicalbenefitresponseinsystemicchemotherapyplushyperthermiagroupwas66%and46.5%insystemicchemotherapygroup.Therewassignificantdeffereneebetweenthetwogroups(P<0.05).ThedifferencewassignificantinthechangeofKPSscorebeforeandaftertreatmentbdeweenthetwogroups.Thetox
7、icandsideeffectsofthetwogroupshadnosignificantdifference.Cone1usionHyperthormiacombincdwithchemotherapyhasbettertoleranceandshort-termefficacyinthetreatmentofpatientswithadvaneedgastriccancer.［KeyWords］Gastriccancer;Diathermy;I厂OHP;Antineoplasticcombinedchemo
8、therapyprotocols;Selftolerance胃癌在我国的发病率和死亡率居各种恶性肿瘤的首位,诊断时75%己为播散性疾病，以全身化疗为主的综合治疗是提高胃癌疗效和生存率的重要方法［1］。我科应用热疗联合全身化疗治疗晩期胃癌，疗效较好,现报道如下。1资料与方法1.1一般资料51例晚期胃癌患者均病理确诊为腺癌，临床诊断为IV期或术后转移，1个月内未接受过其他抗肿
