生活休闲_医药类课件PPT模板.ppt

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1、【般若黑洞】出品NorthwesternPolytechnicUniversity基于大分子的药物控释肿瘤靶向PolymericTumor-TargetingDrugControlledReleaseDrugLoad装载定位TargetingDrugRelease释放胶束Micelles树枝状聚合物DendrimersLiposomes微脂囊聚合物-药物偶联物Polymer-drugconjugatesDrugLoad装载定位主动active被动passiveTargeting配合基-受体Ligand-receptorEPR效应EPREffect叶酸cRGD正常组织癌变部位Dr

2、ugRelease释放pH温度降解磁场UV电场内因外因PDEAEMAPNIPAM-s-s-hydrazonebonds多层分子设计MolecularDesign嵌段分子量端基ATRPRAFT点击化学超分子星形开环Tumor-TargetingPeptideConjugatedpH-ResponsiveMicellesasaPotentialDrugCarrierforCancerTherapyXiangLanWu,JongHoKimTumor-Targeting,pH-Responsive,andStableUnimolecularMicellesasDrugNanocarri

3、ersforTargetedCancerTherapyXiaoqiangYang,JamisonJ.Grailer,SrikanthPillaPEG-SS-PPS:Reduction-SensitiveDisulfideBlockCopolymerVesiclesforIntracellularDrugDeliveryXiangLanWu,JongHoKimFolate-ConjugatedThermoresponsiveBlockCopolymers:HighlyEfficientConjugationandSolutionSelf-AssemblyPriyadarsiDe,

4、SudershanR.Gondi,andBrentS.SumerlinDevelopmentofmultiple-layerpolymericparticlesfortargetedandcontrolleddrugdeliveryBhanuprasanthKoppolu,MS,MahamRahim,OSiOSiOSiSiOSiOSiSiOSiOSiOSiOSiHSiOSiOSiHOSiOSiHSiOSiHNH2NHNH2NHNH2NHNNH2graftedPNIPAMShellβ-CDbasedHBPCoreThermo-ResponsiveHyperbranchedpoly

5、(β-CD)s-g-PNIPAMThankyou!PolymericTumor-TargetingDrugControlledReleaseNorthwesternPolytechnicUniversity