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1、286ChinJNervMentDisVol.36,No.5May2010·论著·2型糖尿病患者的认知功能与血浆BDNF水平☆3△333周红常京豪张志珺滕皋军【摘要】目的探讨2型糖尿病(diabetesmellitus,DM)患者认知功能特征及其与血浆脑源性神经营养因子(brain2derivedneurotrophicfactor,BDNF)水平的关系。方法应用多维度神经心理学量表评估年龄及教育程度相匹配的89例2型DM患者及40例对照者的神经认知功能,并结合Peterson的遗忘型轻度认知功能障碍(
2、amnesicmildcognitiveimpairment,aMCI)标准判定两组中的aMCI患者;采用酶联免疫吸附试验检测血浆BDNF水平。结果2型DM组连线测试B(trialmarkingtestB,TMTB)、听觉词语记忆测试2延迟回忆和再认(delayedrecallandrecogni2tionofauditoryverballearningtest,AVLT2DR&RC)、符号数字转换测试(symboldigitmodulationtest,SDMT),词语流畅性测试(verbalflue
3、ncytest,VFT)及画钟测试(clockdrawingtest,CDT)成绩均明显差于对照组(均P<0.01);2型DM与aMCI有较强的关联性[OR=41032(11536～101582)],2型DM中aMCI者AVLT2DR&RC、VFT、TMTB、CDT、连线测试A(trialmarkingtestA,TMTA)、复杂图形测试2延迟回忆(delayedrecallofRey2Osterrichcomplexfiguretest,CFT2DR)成绩均明显差于2型DM非aMCI组(P<0105)
4、;2型DM组血浆BDNF水平明显低于对照组(P<0101),但与各项认知评估成绩无相关性(P>0105),仅2型DM组aMCI者血浆BDNF水平与SDMT及CFT2DR测试成绩呈正相关(分别为r=01522,P<0101;r=01346,P<0105)。结论2型DM患者可出现认知功能损伤,并伴血浆BDNF水平降低;但2型DM的认知功能改变与BDNF水平之间的关系有待进一步研究证实。【关键词】2型糖尿病认知功能脑源性神经营养因子+【中图分类号】R749.24,R587.1【文献标识码】AThecognit
5、ivefunctionandplasmalevelsofBDNFinpatientswithtype2diabetes.ZHOUHong,CHANGJing2hao,ZHANGZhijun,TENGGaojun.DepartmentofNeurology,ZhongdaHospitalAffiliatedtoSoutheastUniversity,Institu2tionofCerebralVascularDiseaseofSoutheastUniversity,Nanjing.210009.China
6、.Tel:025-83272357.【Abstract】ObjectiveTheaimsofthisstudyweretoinvestigatethecharacteristicsofcognitivefunctioninpa2tientswithtype2diabetes(DM)andtheassociationofthecognitivefunctionintype2DMpatientswithplasmalevelsofbrain2derivedneurotrophicfactor(BDNF).M
7、ethodsEighty2ninepatientswithtype2DMand40nondiabeticcontrolswithageandeducationmatchedwereincludedinthisstudy.Allthesubjectsreceivedasetofmulti2dimensionneuropsychologictestsforthecognitiveassessment,andthediagnosesofamnesicmildcognitiveimpairment(aMCI)w
8、eremademainlyac2cordingtotheresultsofcognitiveassessmentandthecriteriaofaMCIbyPeterson.Anenzyme2linkedimmunosorbentassay(ELISA)wasusedtomeasureplasmaBDNFconcentrations.ResultsTheperformancesoftype2DMgroupinthetrialmarkingt
