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1、地衣芽砲杆菌对非酒精性脂肪性肝病的治疗作用［摘要］目的探讨地衣芽雀杆菌制剂对非酒精性脂肪性肝病的治疗作用。方法选择正常健康人40例作为正常对照纟肛选择临床诊断非酒精性脂肪性肝病患者82例，随机将其分为易善复治疗组和易善复加報肠生治疗组，易善复治疗组41例，口服易善复456mg,3次/d；易善复加整肠生治疗组41例，口服易善复456mg及整肠生0.5g,3次/d,两组均结合低热量饮食、运动等基础治疗，共6周。治疗前、后分别测定肝功能丙飙酸转移酶(ALT)、空腹胰岛素水平(FINS)、胰岛素敛感指数(ISI)、抵抗素(RETN)等。结果治疗前，易善复治疗组和易善复加整肠生治疗组
2、FINS、ALT、RETN、ISI均高于正常对照组(PV0.05)。治疗后，两治疗组FINS、ALT、RETN、1S1比治疗前降低(P<0.05),易善复加整肠生治疗组与易善复治疗组比较，差异有统计学意义(P<0.05)。结论地衣芽砲杆菌制剂可减少非酒精性脂肪性肝病患者耿岛素抵抗(IR),降低肠源性内毒素血症，改善肝功能，可作为非酒精性脂肪性肝病的药物治疗选择。［关键词］地衣芽泡杆菌；非酒精性脂肪性肝病；胰岛索抵抗［中图分类号］R575.5［文献标识码］B［文章编号］1673-7210(2012)01(c)-0154-02TheeffectofBnfilluslicheni
3、formisonnonalcoholicfattyliverdiseaseLIHaitaoWANGWenZHANGZhijianADepartmentofGastrocnterology,FuzhouGencralHospitalofNanjingMilitaryCommand,FujianProvince,Fuzhou350025,China［Abstract］ObjectiveToevaluatetheeffectofBnfilluslicheniformisonnonalcoholicfattyliverdisease(NAFLD)・Methods40healthyv
4、olunteetswereasnorinalcontrolgroup・82patientswithnonalcoholicfattyliverdiseasewererandomlydividedintotwogroups:41patientsreceivedthetreatmentwithpolyenephosphatdylcholine(456mgpo,tid)(polyenephosphatdylcholinegroup);41patientsreceivedpolyenephosphatdylcholine(456mgpo,tid)anclBnfilluslichen
5、iformis(0.5gpo,tid)(polyenephosphatdylcholineandBnfilluslicheniformisgroup).Thebothgroupsweregivenlow-caloriediet,exerciseandothertreatmentfor6weeks.Theparametersweremeasured,whichincludingfastingplasmaresistin,insulinsensitiveindcx(ISI)byfastinginsulin(FTNS),alanineaminotransferase(ALT)be
6、foreandaftertreatment.ResultsBeforetreatment,FINS,ALT,ISIandRETNwerehigherinpolyenephosphatdylcholinegroupandpolyenephosphatdylcholineandBnfilluslicheniformisgroupthanthoseinnormalcontrolgroup(P<0.05).FINS,ALT,RETNandISIsignificantlydecreased(P<0・05)aftertreatment.Polyenephosphatdylcholine
7、andBnfilluslicheniformisgroup'schangesweremoresignificantthanthoseofpolyenephosphatdylcholinegroup(P<0.05).ConelusionBnfilluslicheniformiscandecreaseIRandthelevelsofserumendotoxin,improveliverfunctionofNAFLD.ItisachoiceforNAFLDpatients.［Keywords］Bnfilluslichen
