健脾疏肝方治疗肝郁脾虚腹泻型肠易激综合征的临床研究-论文.pdf

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1、上海中医药杂志2013年第47卷第l2期SH．J．TCMDec．，2013；Vo1．47No．12·43·健脾疏肝方治疗肝郁脾虚腹泻型肠易激综合征的临床研究刘竹轩，一，谢建群，华云玮，林俊儒，柳文1．上海中医药大学睥胃病研究所(上海200032)；2．上海中医药大学附属龙华医院脾胃病科(上海200032)【摘要】目的观察健睥疏肝方治疗肝郁脾虚腹泻型肠易激综合征的临床疗效。方法采用随机对照的研究方法，将80例患者随机分为治疗组和对照组，每组4O例。对照组予曲美布汀片和酪酸梭菌活菌片治疗，治疗组予健脾疏肝方汤剂。两组疗程均为1个月，观察临床疗效及中医证候积分变化情况。结果治疗组、对照组总有效率分

2、别为92．50％、85．00％，组问中医证候疗效差异有统计学意义(尸<0．015)。两组治疗后中医证候总分及各主要症状积分均明显减少(P<0．05)；组间治疗后比较，差异均有统计学意义(P<0．05)。治疗组治疗后，除食后腹胀外，其余次要症状积分明显减少(P<0．05)；对照组食欲减退、食后腹胀积分明显减少(P<0．05)；组间治疗后比较，口苦口黏、精神疲乏、四肢无力、畏寒怕冷、烦躁易急等次要症状积分差异有统计学意义(P<0．05)。结论健脾疏肝方能有效改善肝郁脾虚腹泻型肠易激综合征的临床症状，疗效确切。【关键词】腹泻型肠易激综合征；肝郁脾虚；健脾疏肝方；临床研究【中图分类号】R574【文献

3、标志码】A【文章编号】1007—1334(2013)l2-0043—03Clinicalstudyon“JianpiShuganFormula”forthetreatmentofdiarrhea-predominantirritablebowelsyndromeLIUZhu．xuan’，XIEJian—qunt，HUAYun．wei，LINJun—ru，，LIUWen，。1．Instituteoj’leenandStomachDiseases，ShanghaiUniversityofTraditionalChineseMedicine；2．LonghuaHospitalAffiliatedt

4、oShanghaiUniversityofTraditionalChineseMedicineAbstract：ObjectiveToobservetheclinicaleficacyof“JianpiShuganFormula”intreatingdiarrhea—predominantirritablebowelsyndrome(D—IBS)．MethodsEightycaseswererandomizedintotreatmentgroupandcontrolgroup，with40casesineachgroup．Patientsincontrolgroupweretreatedwi

5、thTrimebutineTabletsandClostridiumButyricumTablets，andpatientsintreatmentgroupweretreatedwith“JianpiShuganFornmla”，withthecourseof1month．TheclinicalefficacyandTCMsymptomscorewereobserved．ResultsThetotaleffectiveratewas92．50％inthetreatmentgroupand85．00％inthecontrolgroup，withadiferencebetweenthetwogr

6、oups(P<0．05)．Aftertreatment，thescoresoftotalTCMsymptomsandmainsymptomsweredecreasedmarkedly(P<0．05)；withsignificantdittbrencebetweenthetwogroups(P<0．05)．Exceptforabdominaldistensionaftereating，thescoresofothersymptomsweredecreasednmrkedlyaftertreatmentintreatmentgroup(P<0．05)；whilethescoresofanorex

7、iaandabdominaldistensionweredecreasedmarkedlyincontrolgroup(P<0．05)；aftertreatment，thereweresignificantdifferencesinthesymptomsofbittertaste，stickyandgreasyinmouth，fatigue，weaknessoflimbs，aversiontocoldandd