非酒精性脂肪性肝病患者幽门螺杆菌感染状况调查.pdf

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1、实用肝脏病杂志2013年10月第16卷第5期JClinHepatol，Oct．2013．Vo1．16N0．5·451··脂肪性肝病·非酒精性脂肪性肝病患者幽门螺杆菌感染状况调查木郭晓燕史海涛师阿盟王婷董蕾【摘要】目的探讨非酒精性脂肪性肝病(NAFLD)患者幽门螺杆菌(Hp)的感染状况。方法在946例NAFLD患者和3725例健康对照人群，采用免疫胶体金法检测血清抗幽门螺杆菌尿素酶抗体。结果在男性中。NAFLD和对照组人群Hp感染率分别为21．3％和21．6％(尸>0．05)，在女性分别为14．9％和16．6％(尸>0．05)；在男性中，轻、中和重度NAFLD患者Hp感染率分别为21．9％

2、、20．8％和17．4％(尸>0．05)，在女性分别为16．4％、16．7％和15．0％(尸>O．05)；Hp阳性与Hp阴性人群体重指数、肝功能和血脂水平亦无明显差异。结论幽门螺杆菌感染可能对NAFLD发病、肝功能指标、血糖及血脂水平无明显影响。【关键词】非酒精性脂肪性肝病；幽门螺杆菌；肝功能；血糖；血脂doi：10．3969／j．issn．1672—5069．2013．05．022Theprevalenceofhelicobacterpyloriinfectioninpatientswithnon—。alcoholicfattyliverdiseaseGuoXiaoyan，ShiHai

3、tao，ShiAmeng，eta1．SecondAfiliatedHospitalofMedicine，Xi"anJiaotongUniversitySchoolofMedicine，Xi"an710004，ShaanxiProvince，China【Abstract】ObjectiveToinvestigatetheprevalenceofhelicobacterpylori(Hp)infectioninpatientswithnon—alcoholicfattyliverdisease(NAFLD)．MethodsSubjectsunderwentphysicalexaminatio

4、nwerestudied．Ab—dominalBultrasoundandserumHpantibodywereusedtodeterminetheexistenceofNAFLDorHpinfection，respectively．Atotalof946patientswithNAFLD(658malesand288females)and3725healthcontrols(1867malesand1858females)wereenrolled．ResultTherewasnostatisticalsignificanceinHpinfectionratesbe-tweentheNA

5、FLDpatients(21-3％)andthehealthcontrols(21．6％，P>0．05)inthemale，neitherinthefemale(14．9％inNAFLDpatientsVS．16．6％inhealthcontrols)；TheprevalenceofHpinfectioninpatientswithmild，moderate，orsevereNAFLDwere21．9％，20．8％and17．4％respectivelyinthemaleand16-4％，16．7％and15．0％respectivelyinthefemaleandthedifferen

6、ceswerenotstatisticallysignificantineithergender(P>0．05)；Liverfunctionparameters，bloodglucoseandlipidslevelswerenotsignificantlydifferentbetweenpersonswithserumanti-Hpantibodypositiveandwithitnegative．ConclusionHelicobacterpyloriinfectionmaynotcontributetothepathogenesisofNAFLDanddonotaffectliver

7、function，bloodglucoseandlipidslevels．【Keywords】Non—alcoholicfattyliverdisease；Helicobacterpylori；Liverfunctiontests；Bloodglucose；Bloodlipids幽门螺杆菌(Helicobacterpylori，Hp)是一种定植国人群Hp感染因地区有所不同，20％～90％不等。Hp于胃粘膜的革兰阴性螺旋形致病菌。流行