大孔吸附树脂分离纯化迷迭香中迷迭香酸的研究

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1、大孔吸附树脂分离纯化迷迭香中迷迭香酸的研究【摘要】 目的考察大孔吸附树脂对迷迭香酸的吸附性能和纯化效果，寻找从迷迭香中分离纯化迷迭香酸的较优工艺。方法以迷迭香酸的吸附量、解吸率和所得粉末中迷迭香酸的含量为指标，从4种大孔吸附树脂中筛选出较好的D101树脂。通过静态和动态实验，对迷迭香酸在D101树脂上吸附和解吸的条件进行考察和优化。结果采用D101树脂从迷迭香中分离纯化迷迭香酸的较优工艺参数为：上柱液pH3～4，速度2BV/h，溶液处理量9BV，洗脱剂为40%乙醇，洗脱速度1BV/h，收集洗脱液3BV。按此工艺条件，迷迭香酸的解吸

2、率为94.8%，3BV洗脱液浓缩干燥后，所得粉末中迷迭香酸含量为23.7%，树脂经8次重复使用，吸附量和分离效果无明显下降，可以重复使用。结论D101树脂可从迷迭香中较好的分离纯化迷迭香酸，具有潜在的工业应用价值。【关键词】 迷迭香酸；大孔吸附树脂；迷迭香；分离；纯化    ChinaAbstract:ObjectiveToevaluatetheabsorptioncapabilityandpurificationeffectofrosmarinicacidonmacroporousabsorptionresin,andtofin

3、dabettermethodtoseparateandpurifyrosmarinicacidfromRosmarinusofficinalisL..MethodsMacroporousresinD101wasmoresuitablefortheseparationandpurificationofrosmarinicacidamongfourkindsofresinsselectedwithabsorptioncapacity,desorptionratioandthecontentofrosmarinicacidinthepo

4、wderobtainedascriteria．Optimalconditionsforabsorptionandelutionofrosmarinicacidwereperformedwithstaticanddynamicexperiments.ResultsTheresultshowedthattheoptimumtechnologyparameterswereasfollows：thepHvalueofsolution3to4,flowrate2BV/h,solutiontreatmentcapacity9BV,andros

5、marinicacidabsorbedcanbedesorbedby40%alcoholatflowrate1BV/h,andcollected3BVeluent.Thedesorptionratioofrosmarinicacidwas94.8%accordingtotheabsorptionanddesorptionconditionsabove,andthecontentofrosmarinicacidinpowderobtainedfrom3BVeluentthroughconcentrationanddrywas23.7

6、%.Aftereighttimesofrepeateduse,theabsorptioncapabilityandseparationeffectofthemacroporousresinwasnotdecreasedobviously,andthemacroporousresincouldberecycled.ConclusionRosmarinicacidinRosmarinusofficinalisL.canbeeffectivelyseparatedandpurifiedwiththemacroporousabsorpti

7、onresinD101,andhasthepotentialapplicationvalueinindustry.　　Keywords:Rosmarinicacid