碘-125放射粒子组织间植入治疗恶性肿瘤.ppt

《碘-125放射粒子组织间植入治疗恶性肿瘤.ppt》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、PrimaryClinicalStudyofCT-guidedIodine-125SeedImplantationTherapyinPatientswithAdvancedPancreaticCancer上海交通大学医学院附属瑞金医院卢湾分院王忠敏Brachytherapy1898年居里夫人发现镭1905年即进行了第1例镭针插管治疗1930年Paterson及Parker建立了曼切斯特（Manchester）系统1935年小居里夫妇发现了人工放射性同位素80年代中期，现代近距离治疗迅速发展生物学优势（外放疗相比）肿瘤局部治疗的持续

2、时间长放射治疗的剂量较低对周围正常组织的损伤小对肿瘤细胞的杀伤力强ImplantradioactiveseedsintotumorsEmitcontinueouslowenergyγraysInjuryoftissuesandcellsCelldeathandmutationleadingtocancerInteractwithbiomacromoleculeAnimalexperimentClinicalresearchHumanpancreaticcancerSw1990cellBABL/cwasinoculatedintot

3、hedorsalsideofrightlowerextremityinguinalregionofnudemicePassagedfor3timssubcutaneously,initiatetheexperimentsaftertumorformationwasstablizedExperimentaldesignSubcutaneouspancreaticcancerxenograftinnudemiceSeedimplantationgroupControlgroupExperimentalmethodChangeofxen

4、ograftvolumeinnudemiceComparisonoftumorinhibitionrateObviousliquefactionnecrosiscanbeseeninthecenteralareaofExperimentalgrouptumor,therearesparsecellsaroudthenecrosisarea(×100)HEstainingThereisnoorlittlenecrosisareaincenterofcontrolgrouptumor,therearemultipletumorcell

5、s(×100)ExperimentalgrouppositiveTK1stainingcellsareexiguous（×200）ControlgrouppositiveTK1stainingcellsareabundent（×200）HEstaining碘-125放射粒子组织间植入治疗属放射治疗，对周围正常器官组织无明显放射损伤裸鼠移植瘤组织植入碘-125粒子后，实验组心、肺、肝、肾、脾脏外观大致正常，病理检查未见明显放射性炎症表现PreliminaryresultZM.WangMD,ShanghaiRuijinHospital

6、IntroductionPancreaticcancerisadevastatingdiseaseandtheprognosisremainspoorFewpatientsareeligibleforcurativesurgicalresectionAlternativetherapeuticoptionsareindemandTraditionaltherapyvs.Externalirradiationtherapyvs.percutaneousseedimplantationZM.WangMD,ShanghaiRuijinH

7、ospitalExternalirradiationtherapywasregardedasinsensitivetopancreaticcancerandassociatedwithmoresystemicsideeffectsRadioactiveiodine-125seedimplantationhasminimalsurgicaltraumaandfewcomplicationsThemostcommonlyusedisotopeisiodine-125125Iplacementwasroutinelyusedatouri

8、nstitutionforrecurrenttumorsatvarioussitesTheaimofthisstudywastotestitsfeasibilityforpancreaticlesionsCurrentControversies11