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《巴西莓对大鼠酒精性肝损伤保护作用的研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·788·中国热带医学2014年第14卷第07期ChinaTropicalMedicine,July2014,Vo1.14,No.07-论著·巴西莓对大鼠酒精性肝损伤保护作用的研究屈胜胜,张建军,王淳,李艳霞,杨旭,王林元北京中医药大学,北京100029摘要:目的研究巴西莓对大鼠慢性酒精性肝损伤的保护作用及机制。方法Wistar大鼠适应性喂养一周后随机分为空白组,模型组,东宝肝泰组,巴西莓1.6g/kg、0.8g/ks、0.4g/kg~.个剂量组,除空白组给蒸馏水外,其余各组均用56%-锅头白酒灌胃,用量为
2、第一周O.8mL/100g,以后每周增加O.1mL,直至增加至1.5mL/100g,连续灌胃8周,建立大鼠慢性酒精性肝损伤模型,观察巴西莓冻干粉对大鼠慢性酒精性肝损伤血清TG、CHO,肝细胞病理改变及II,.8,NF—KB,Nrf-2等的影响。结果巴西莓可以降低血清TG、CHO、II,_8(P<0.01),下调肝脏NF—KB(RO.01),上调Nrf-2mRNA(R0.05)表达。病理切片可见模型组的肝细胞肿胀,可见大小不等的脂肪空泡,局部处可见点状坏死和炎性细胞浸润,阳性药及巴西莓各剂量对大鼠肝脏病理改变
3、有不同程度的改善作用。结论巴西莓对慢性酒精性肝损伤具有一定的保护作用,其机制可能与抑制IL_8,下调NF—KB,上调Nrf-2mRNA表达有关。关键词:巴西莓;酒精性肝损伤;抗氧化;抗炎中图分类号:R392.11文献标识码:A文章编号:1009-9727(2014)7-788-04ProtectiveefectofacalOI3chronicalcoholichepaticIesionsinratsQuSheng-sheng,ZHANGJiaran,WANGChun,LIYan-xia,YANGXu,WAN
4、GLin-yuanBegUnwe~ityofTraditionChineseMedicineBenglO0029,P.R.ChinaCorrespondingauthor:WANGLin-yuan,E-mail:13381002202@rip.163.comAbstract:ObjectiveTostudytheprotectiveefectofacai(EuterpeOleraceaeMart.)onchronicalcoholichepaticinjuryinratsanditsmechanism.Me
5、thodsWistarratswererandomlydividedintonormalcontrolgroup,modelgroup,controlgroup,highdosageacaigroup,mid-dosageacaigroupandlowdosageacaigroup(withdosesof1.6g/kg,O.8g/kgand0.4g,l【.Theratsinblankcontrolgroupweregivenstilledwater,thoseinothergroupswereallintr
6、agastrieallygiven56*liqorwiththedosesof0.8mL/100ginthefirstweekandincreased0.tmLeachweekstartingfromthesecondweek.untilreachthedoseof1.5mL/100gattheeighthweek.TheefectofacaipowderontheselalmlevelsofTG,CHO,IL一8,NF—KB,Nf-2,thepathologicalchangesofhepaticlobu
7、lesinthemodelgroupwereobserved.ResultsAcaicouldsignificantlyreducetheserumlevelsofTG,CHOandIL-8(P8、fatemptybubblesofdiferentsizesincytoplasm,focalnecrosisandinfiltrationofinflammatorycells.Acaishowedalleviatingefectonpathologicalchangesofratliverwithvaryingdegreeineachacaidosegroups.ConclusionTheresultsind
8、fatemptybubblesofdiferentsizesincytoplasm,focalnecrosisandinfiltrationofinflammatorycells.Acaishowedalleviatingefectonpathologicalchangesofratliverwithvaryingdegreeineachacaidosegroups.ConclusionTheresultsind
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