p27、pcna与iga肾病中医证型及病理类型的关系

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1、福建中医学院2002届硕士研究生学位论文中医内科学专业王伟TheRelationshipamongP27,PCNA,PathologicalClassificationandZhengdifferentiation-classificationofIgAnephropathyMajor:InternalmedicineofTCMPostgraduate:WangWeiTutor:Prof.RuanShiweiABSTRACTObjective:ToobservetheexpressionofP27a

2、ndPCNAformparaffin-embeddedrenaltissuesectionsofpatientswithIgAnephropathyandexploretherelationshipamongP27,PCNA,pathologicalclassificationandZhengdifferentiation-classificationofIgAnephropathy.Methods:Applyrenalbiopsyto48casesofprimaryIgAnephropathyan

3、dthespecimenofrenalhadbeenexaminedwithroutinepathologicalmethodandimmunohistochemistry.AllthepatientswithIgAnephropathyinthestudywereclassifiedintothreegroupsbasedonZhengdifferentiation-classification,suchasliver第30页共30页福建中医学院2002届硕士研究生学位论文中医内科学专业王伟kid

4、neyyininsufficiency,qi-yinastheniaanddampness-heart(TCM).Thehistologicalgradewasdividedintofourgrades.Results:1.ThenumberofPCNA+correlatedwithhistologicalgrade(rs=0.336,P<0.05).AnegativecorrelationwasalsofoundbetweenP27+andhistologicalgrade(rs=-0.563,P

5、<0.01).2.Thehistologicalgradeofqi-yinastheniaishigherthanthatofdampness-heart(TCM)andtheliverkidneyyininsufficiency.Therewasnodifferencebetweendampness-heart(TCM)andtheliverkidneyyininsufficiencyinstatistic.3.（1）ThelevelofP27indampness-heart(TCM)wassig

6、nificanthigherthanthatinqi-yinasthenia.（2）ThelevelofPCNAinqi-yinastheniawassignificanthigherthanthatindampness-heart(TCM).（3）ThelevelofP27intheliverkidneyyininsufficiencywashigherthanthatinqi-yinasthenia.（4）ThelevelofPCNAinliverkidneyyininsufficiencywa

7、shigherthanthatindampness-heart(TCM).Inaword,thelevelofP27indifferentZhengdifferentiation-classificationdecreasedaccordingtothefollowingsequence:dampness-heart(TCM),tliverkidneyyininsufficiency,qi-yinasthenia.Onthecontrary,thelevelofPCNAincreasedinthes

8、amesequence.Conclusion:1.P27andPCNAcouldbeusefulingradingrenal第30页共30页福建中医学院2002届硕士研究生学位论文中医内科学专业王伟damagehistologicallyandpredicatingprogressofIgAnephropathy.2.ThehistologicalgradeofdifferentZhengdifferentiation-classificationwassignifi