抑郁症状与血清氧化应激以及炎症反应的相关性研究

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1、授予单位代码10089学号或申请号14125中国图书分类号R749HebeiMedicalUniversity硕士学位论文学术学位抑郁症状与血清氧化应激以及炎症反应的相关性研究研究生：张永艳导师：安翠霞教授专业：精神病与精神卫生学二级学院：第一医院2018年3月目录中文摘要······································································································1英文摘要················································

2、······················································3英文缩写······································································································5研究论文抑郁症状与血清氧化应激和炎症反应的相关性研究前言······································································································

3、6材料与方法······················································································8结果····································································································16附表·····························································································

4、·······19讨论····································································································25结论····································································································27参考文献·······································································

5、······················28综述防治抑郁症的药物靶点研究进展···················································31致谢····································································································40个人简历···························································································

6、41抑郁症状与血清氧化应激以及炎症反应的相关性研究摘要目的：观察抑郁症患者的血清中氧化应激指标（MDA、NO、SOD和GSH-Px）以及炎症反应指标（TNF-α、IL-1、IL-6）治疗前后的变化，并探讨HAMD评分和上述指标的相关性。方法：本研究选择2016年1-9月期间我院40名抑郁症患者作为治疗组，另选择40名健康志愿者作为正常对照组。药物治疗组第一周每天早餐后服用75mg文拉法辛缓释胶囊，第二周开始一直到第八周每天早餐后服用150mg文法拉辛缓释胶囊。评估指标包括汉密顿抑郁量表以及血清中的炎症因子包括TNF-α、IL-6和IL-1，氧化应激指标MDA（Malondial

7、dehyde）和NO（Nitricoxide）的含量，以及SOD（Superoxidedismutase）和GSH-Px（Glutathionperoxidase）抗氧化酶的活力。结果：1.治疗组和健康对照组的性别构成、年龄、BMI、平均发病年龄、收缩压、舒张压、心率、体温、呼吸次数均无统计学差异。2.治疗前，两组HAMD评分有统计学差异（t=7.752，P<0.001）；治疗后，两组HAMD评分无统计学差异（t=1.773，P<0.001）。8周时，治疗组HAMD评分下降，差异有统计学意义