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1、SsCT引导下1251粒子植入联合全身化疗治疗晚期非小细胞肺癌的临床观察林辉苏香花肖建宏彭锦芸(福建医科大学附属闽东医院呼吸科福建福安355000)【摘要】FI的探讨观察CT引导丁1251放射性粒子植入联合吉西他滨、顺钥(GP方案)化疗治疗晚期非小细胞肺癌(NSCLC)的临床疗效和安全性。方法66例IIIb〜IV期NSCLC患者分为(实验组)30例：采用CT引导K粒子植入联合全身化疗和(对照组)36例：化疗组，两组化疗方案均为吉西他滨联合顺铂，术后I、3、6个月分别进行随访做CT检查，观察各&有效率和毒副反应。结果实验组和对照
2、组的总体有效率分别为80.00%和50.00%,两组间有显著的统计学差异(p<0.05),所有的不良反应及并发症可控，实验组有较高的血痰和胸痛、气胸发生率(p<0.05),两组在发热、骨髓抑制方面无差异((p>0.05»，所有患者末出现放射损伤症状、未发现粒子迁移。结论放射性粒子1251植入联合化疗治疗晚期非小细胞肺癌有较好的近期临床疗效和可以控制的毒副不良反应，是晚期非小细胞肺癌安全、有效的治疗手段。【关键词】非小细胞肺癌放射性粒子1251化疗近距离放疗【屮图分类号】R730.5【文献标识码】A【文章编号】
3、2095-1752(2013)13-0118-03CurativeEffectofCT-guided1251seedsimplantationcombinedwithchemotherapyforAdvancedNon-smallcellLungCancerLinHuiSuXiang-hua,XiaoJian-hong,PengJin-yunRespiratorydepartmentofMinDonghospitalofFuJianMedicaluniversity,FuAnFuJian,China,355000【Abstra
4、ct】ObjectiveToexplorethecurativeeffectandsafetyofCT-guidedradioactive1251seedsimplantationcombinationwithGPregimen(GEM+DDP)chemotherapyforadvancednon-smallcelllungcancer(NSCLC).MethodsThe66casesNSCLCpatients(Illb〜IVstage)wererandomlydividedintotwogroups:CT-guidedsee
5、dsimplantationcombinedwithchemotherapygroup(experimentalgroup,n=30)andpurechemotherapygroup(controlgroup,n=36),twogroupswerebothacceptedGPregimen(GEM+DDP)chemotherapy.AndtheywerefollowedupbyCTexaminationafterI,3,6months.Theefficacyandadverseeffectsofbothgroupswereco
6、mpared.ResultsIntheCT-guidedseedsimplantationcombinedwithchemotherapygroupandthepurechemotherapygroup,theresponserate(CRplusPR)was80.0%and50.0%,respectively.Thereweresignificantdifferencesintwogroups(p<0.05).Alltheadversereactionsandcomplicationswerecontrollable.
7、Theexperimentalgrouphadhigherbloodysputum,chestpainandpneumothoraxincidence(p<0.05),but,therewerenosignificantdifferencesinfeverandbonemarrowsuppression.Therewerenoradiationinjurysymptomsandparticlemigrationinallpatients.ConclusionItwasbetternear-termclinicaleffi
8、cacyandwascontrollabletoxicityintheCT-guidedseedsimplantationcombinedwithchemotherapygroup.So,itwasansafeandeffectivetreatmentforadvancedn
