2型糖尿病骨密度与颈动脉粥样硬化关系的初步探讨

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1、英文摘要ThePreliminaryInvestigationoftherelationshipbetweentheBMDintype2diabeteswithcarotidatherosclerosisObjective：Osteoporosisandatherosclerosisarethemaincauseofmorbidityandmortalityintheagedpeople．Theywereconsideredastwoindependentdiseaseprocess．Inpresentstudy，bonedensityshowedobviouslycorrel

2、ationwithseverityofatherosclerosisafterjudgementoftraditionriskfactorsofcardiovasculardisease．Bonelossoffemoralincreasedmortalityofcardiovasculardisease．Vascularcalcification，anotablefeatureofatherosclerosis，wasalsoapredictivefactorsoffractureoffemur．Indiabetespatientsandpostmenopausalwomen，

3、peoplewithosteoporosisfrequentlydisplayvasculardisease，soosteoporosisandatherosclerosismaybesharedwiththecommonriskfactorsandepidemiologicalchanges．Severalstudiesalsoindicatedthatatheroscleroticcalcificationasanorganizedandregulatedprocesssimilartoboneformation．Localregulationofmineralizatio

4、ninboneandvesselsissupportedbysimilarcomplexcellularresponsesandlocalmodulators．Inordertoinvestigatetherelationshipbetweendiabeticosteoporosisandathemsclerosis，ThisstudywasconductedtomeasureBMDofthe“乃圳lumbarvertebraeandleft英文摘要femurasanindexofosteoporosisandtheintima’mediathickness(IMT)ofthe

5、carotidarterywasmeasuredasallindexofatherosclerosis．ThenthecorrelationbetweenBMDandIMTWasexamined．Methods：Inthisstudy,52postmenopausalwomenwithtype2diabetesmellitus，50healthynon—diabeticpostmenopausalWomenweremadeascontrolgroup．AllsubjectswereevaluatedforBMDatU2)一L‘4)lumbarvertebraeandthefem

6、ur(neck,trochanter,InterTroandtotal)byDEXA(dualenergyX-rayabsorptiometry)，andforIMTbyColorDopplerUltraSoundequipment．Diabeticduration，FBGPBGandotherindexesetalwererecorded,thenthesedatawereevaluatedforanyrelationshipinrespecttoBMDandIMTmea跚rements．Characteristicsofsubjectobtained：①BMDweremea

7、suredbyOSTEOCORE3madeinMEDILINK(France)②liTweremeasuredbySEQUOIA512(耍)hemoglobinAleinbloodweredeterminedbyDCA2000+(BayerCo．Germany)．(分fastingplasmainsulin(V矾S)，weremeasuredwithradioimmunoassay．‰patients’highandweightwererecorded，b00ymassindexWascou