经肝动脉灌注不同化疗药物联合肝动脉栓塞治疗中晚期肝细胞癌的临床研究

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1、授予单位代码10089学号或申请号132'13K^(i^ASHebeiMedicalUniversity硕士学位论文在职科学学位经肝动脉灌注不同化疗药物联合肝动脉栓塞治疗中晚期肝细胞癌的临床研究学位申请人：李淑玲导师：孔丽教授专业：内科学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专

2、利等知识产权均归河北医科大学所有。否则,承担相应法律责任。/急大喪/',、,7*一,•、..•fi；.\‘••研究生签名导师签章：二级学院领导盖章：m年j月>]：日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：欠年月从日认定号：13213河北医科大学在职人员申请硕士学位论文经肝动脉灌注不同化疗药物联合肝动脉栓塞治疗中晚期肝细胞癌的临床研究研究生姓名：李淑

3、玲二级学院：河北医科大学第三医院指导教师：孔丽教授申请学位类别：硕士研究生专业名称：内科学起止日期：2012．12-2014．12交稿日期:2015.03目录中文摘要················································································1英文摘要················································································4英文缩写··························

4、······················································8研究论文经肝动脉灌注不同化疗药物联合肝动脉栓塞治疗中晚期肝细胞癌的临床研究前言················································································9材料与方法·····································································10结果··························

5、····················································15附图··············································································19附表··············································································21讨论···························································

6、···················27结论··············································································31参考文献·······································································32综述肝癌TACE治疗现状及进展………………………………………36致谢·································································

7、···················47个人简历··············································································48中文摘要经肝动脉灌注不同化疗药物联合肝动脉栓塞治疗中晚期肝细胞癌的临床研究摘要目的：探讨不同化疗药物（雷替曲塞、替加氟）行肝动脉灌注化疗联合吡柔比星、奥沙利铂碘油乳剂肝动脉栓塞治疗中晚期肝细胞癌的临床疗效及安全性，为临床治疗中晚期肝细胞癌提供实践依据和理论依据。方法：研究对象选取河北大学附属医院2011年12月-2014年1月确诊的89例肝细胞癌

8、患者，诊断符合2011年中国抗癌协会肝癌专业委员会修订的肝癌临床诊断标准。所有患者均经临床症状