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1、胰岛素治疗新诊断的2型糖尿病患者血糖控制的远期效果［摘要］目的探讨胰岛素对2型糖尿病患者血糖控制的远期疗效。方法选择北京中医药大学东直门医院东院区2011年5月〜2012年12月收治入院新诊断的2型糖尿病患者100例临床资料进行回顾性分析，观察空腹血糖、三餐后2h血糖、空腹胰岛素水平、空腹C肽及糖化血红蛋白(HbAlc),对比胰岛素强化治疗前、治疗2个月后，治疗1年后空腹及餐后2h血糖、空腹胰岛素水平、空腹C肽及HbAlco结果本组100例新诊断2型患者采用胰岛素强化治疗后空腹及餐后2h血糖均有明显下降，胰岛水平及C肽有所改善。治疗2个月及1年
2、后空腹及餐后2h血糖、空腹胰岛素水平、空腹C肽及HbAlc与治疗前比较差异均有统计学意义(P<0.05)；所有患者均随访1年以上，患者仅需口服少量降糖药物治疗即能维持良好血糖控制。结论强化胰岛素治疗可以显著恢复代表胰岛B细胞功能的血糖、胰岛素浓度、C肽，使患者的糖尿病回到2型糖尿病自然病程的更早期阶段，其总体疗效明显，治疗初诊2型糖尿病，能取得较好的血糖控制及预后，值得临床推广。［关键词］胰岛素；新诊断；2型糖尿病；血糖控制；疗［中图分类号］R587［文献标识码］A［文章编号］1673-7210(2014)05(c)-0075-04Longte
3、rmeffectofinsulinonbloodglucosecontrolintype2diabeticpatientswithnewlydiagnosedWANGYanjieMIAOGuizhenCAOBailongZHUXueminLIChunguiMIAOJuanWANGLiqiangWANGJingliangEastBranchofDongzhimenHospital,BeijingUniversityofChineseMedicine,Beijing101121,China［Abstract］ObjectiveToexploreth
4、ecurativeeffectoftype2diabeticinsulintherapyinnewlydiagnosedforgoodglycemiccontrol.MethodsTheclinicaldataof100casesoftype2diabeticpatientsinEastBranchofDongzhimenHospital,BeijingUniversityofChineseMedicinefromMay2011toDecember2012wereanalyzedretrospectively.Thelaboratoryexam
5、inationoffastingbloodglucose,2hbloodglucoseaftermeals,fastinginsulin,fastingCpeptideandHbAlcwereobservedandcomparedwithintensiveinsulintherapybeforeandafter2monthsoftreatment,andHbAlc2hbloodglucose,fastinginsulin,fastingCpeptideafter1yearoftreatmentoffastingandpostprandial.R
6、esults100casesofpatientswithnewlydiagnosedtype2diabetesusingintensiveinsulintherapyafterfastingand2hpostprandialbloodglucoseweresignificantlydecreased,andCpeptideimprovedislet.Both2hbloodglucose,fastinginsulin,fastingCpeptideandHbAlcbeforeandaftertreatmentweresignificantdiff
7、erentfortwomonthsand1yearafterfastingandpostprandial(P<0.05);allthepatientswerefollowedupformorethan1year,onlyafewpatientswithoralhypoglycemicdrugtreatmentthatcouldmaintaingoodbloodglucosecontrol.ConclusionIntensiveinsulintherapycansignificantlyrestorebloodglucose,insulin,Cp
8、eptideonbehalfofisletbetacellfunctioninearlystage,makethepatientswithdiabet
