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1、REFLECTIONSThispaperisavailableonlineatwww.jbc.orgTHEJOURNALOFBIOLOGICALCHEMISTRYVOL.283,NO.22,pp.14901–14909,May30,2008©2008byTheAmericanSocietyforBiochemistryandMolecularBiology,Inc.PrintedintheU.S.A.InSearchoftheMessagePublished,JBCPapersinPress,March31,2008,DOI10.1074/jbc.X800001200JohnH.ExtonFr
2、omtheDepartmentofMolecularPhysiologyandBiophysics,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee37232-0615wasborninAuckland,NewZealand,in1933.HitlerwasontheriseinGermany,butthiswasoflittleconcerntomostoftheinhabitantsofthisbeautifulcountrysofarfromthepolitical,Ieconomic,andculturalcenterso
3、ftheworld.Duringmyearlyyears,myfamilylivedbytheseaside,andmysisterandIledanidyllicexistenceplayingonthebeach,exploringrockpoolsteemingwithlife,andclimbingthecliffstoseethenestsofoceanbirds.MyexposuretotheuniquefloraandfaunaofNewZealandengenderedanearlyinterestinbiology.IleftallthisbehindwhenDownload
4、edfrommyfamilymovedtothecity,wheremyeducationbeganinearnest.ThiswaswhenatomicbombsweredroppedonJapantoendWorldWarII.Ididnotrecognizethemoralissuesinvolvedinthisact,butitstimulatedmyintenseinterestinnuclearphysics.IwasprobablyoneoffewelementaryschoolpupilsinNewZealandwhoreadaboutMadameCurie,NielsBohr
5、,MaxPlanck,ErnestLawrence,EnricoFermi,WalterHeisenberg,ErwinSchro¨dinger,and,ofcourse,NewZealand’shttp://www.jbc.org/ownErnestRutherford.Formysecondaryeducation,IwassenttoaChurchofEnglandpreparatoryschoolthatwaspatternedafteranEnglishpublicschool.Disciplinewassevere,withthecanebeingliberallyapplieda
6、ndbullyingrampant.However,myparentsdidnotpayhighfeesjustfortheinflictionofbyguestonAugust12,2018painontheirson,butforanexcellentacademicprograminwhichLatinwasmandatoryandGreekrecommended.Thisclassicaleducationwasbroadenedbyexposuretohistoryandliterature,almostexclusivelyBritish,andtomathematicsandth
7、esciences.Forsport,wewererequiredtoplaycricketandrugbyfootballwhateverourcompetence,whichinmycasewaslow.Thechem-istryteacherfrequentlyputondramaticexplosivedisplaysofchemicalreactions,causingustocrouc
