三七总皂苷脉冲迟释片体外释放度影响因素研究-论文.pdf

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1、·药物研究·中l虱茜2014年8月5日第23卷第l5期DrugResearchChinaPharmaceuticalsVo1．23，No．13，August5，2014三七总皂苷脉冲迟释片体外释放度影响因素研究奚炜，胡熙曦，陈进兵，金桂兰，邢翔飞，黄久华。(1．三峡大学人民医院·湖北省宜昌市第一人民医院药剂科，湖北宜昌443000；2．湖北省枝江市人民医院药剂科，湖北枝江443200)摘要：目的考察三七总皂苷脉冲迟释片的体外释放度，初步判断其主药成分人参皂苷Rg一在体内的吸收速率和程度。方法制备三七总皂苷脉冲迟释片，考察

2、其在不同介质、不同方法及不同转速下人参皂苷Rg-的释放度。结果溶出介质的pH对释放度无显著影响，释药时滞会随介质黏度的增加而延长；转篮法较桨法稳定，更适合该制剂的释放度研究；不同转速对释药时滞无显著影响，对释药速率略有影响。所制备的三七总皂苷脉冲迟释片在体外释放过程中延迟4～5h后，快速脉冲式地释药。结论根据时辰药理学原理，三七总皂苷脉冲迟释片的体外释放符合其用于心血管疾病预防和治疗的目的。关键词：三七总皂苷脉冲迟释片；体外释放度；转篮法中图分类号：TQ461；R286．0文献标识码：A文章编号：1006—4931(20

3、14)15—0020—03InfluencingFactorsofinVitroReleaseofPanaxNotoginsengSaponinsPulseDelayedReleasingTabletxiWei1，HuXixii，ChenJinbing

4、，finGuilant，XXiangfeii，HuangJiuhua2f．DepartmentofPharmacy，PeoplesHospital，ChinaThreeGorges￡，而‘TheFirstHospitalofHchang,Hchang,Hubei，Chin

5、a443000；2．DepartmemofPharmacy,ZhijiangMunicipalPeoplesHo~ital，Zhijiang,Hubei，China443200JAbstract：ObjectiveToinvestigatetheinvitroreleaseofPanaxNotoginsengSaponins(PNS)PulseDelayedReleasingTabletandtopreliminarilyjudgetheinvivoabsorptionrateanddegreeofthemaindrug

6、ingredientsginsenosideRgjinthispreparation．MethodsPNSPulseDelayedReleaseTabletswaspreparedandthereleasingrateofginsenosideRglindifferentmedia，differentmethodsanddifferentrotationspeedswasinvestigated．ResultsThepHofthedissolutionmediumhadnosignificanteffectODthere

7、leasingrate，andreleasedelaycouldbeextendedwiththeincreaseofthemediumviscosity；therotatingbasketmethodwasmorestablethanthepaddlemethodandmoresuitableforthestudyonthereleaserateofthispreparation；differentrotatingspeedshadnosignificanteffectonthereleasedelayandsligh

8、tlyafectedthereleaserate．PNSPulseDelayedReleaseTabletspreparedbythisstudywasrapidlyreleasedinpulsetypeafterdelayingfor4—5hduringtheprocessofinvitrorelease．ConclusionAccordingtothechronopharmacologyprinciple，theinvitroreleaseofPNSPulseDelayedReleaseTabletsconforms

9、toitspurposesforpreventingandtreatingcardiovasculardisease．Keywords：PanaxNotoginsengSaponins(PNS)PulseDelayedReleasingTablet；drugreleaseinvitro；rotatingbasketm