间叶性软骨肉瘤3例临床病理观察-论文.pdf

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1、现代肿瘤医学2014年7月第22卷第7期MODERNONCOLOGY，Ju1．2014，VOL．22，NO．07·1669·．．．骨·软组织肿瘤．．．间叶性软骨肉瘤3例Ilk床病理观察方三高，马强，林俐，杜娟，钟鹏，肖华亮Mesenchymalchondrosarcoma：ACIinlCOpath0lOgiCaIanalysisof3casesFangSangao，MaQiang，LinLi，DuJuan，ZhongPeng，XiaoHualiangDepartmentofPathology。DapingHospitalandResearchInstituteofsugery，theThir

2、dMilitaryMedicalUniversity，Chongqing400042，China．【Abstract】Objective：Toinvestigatetheclinicopathologicfeatures，diagnosisanddifferentialdiagnosisofmesen—chymalchondrosarcoma(MC)．Methods：ThreecasesofMCwereanalysedhist0path010gicallyandradiologicallywithreviewoftherelatedliterature．Reslllts：Allpatient

3、swereadultswithanaverageageof42．3．Thecardinalclinicalpresentationswerepain，swelling，localmasswithorwithoutcompressionsymptoms．Tumorswerelocatedincerebellartentorium，leftchestwallandsacrum，respectively．Imagerevealedaneoplasmwithanosteolyticanddestructiveprofileaccompaniedwithstippleormottledcalcific

4、ation．Grossly，thetumorsshowedassofttofirmwithgrey—whitecutsur—faceanddottedwithirregularmineralizeddeposits．Microscopically，thetumo~werecomposedofabundantundiferen—tiatedcellsandscatteredislandsofhyalinecartilage．Inthesmallbluecellareas，tumorcellswereprimitive，roundtoshortspindlewithscantycytoplasm

5、s，andarangedinsheetorhaemangiopericytoma—likepattern．Inthecomponentsofchondrocyte，however，thecellswererelativelymatureandwell—differentiated．Bothcomponentsjuxtaposedsharplytoorblendedgraduallywitheachother．Immunohistochemically，itwasdiffuselypositiveforvimentinin3cases，andpartlypositiveforCD99inund

6、ifferentiatedcellzones．Meanwhile，itwaspositiveforS一100incartilaginousdiferen—tiationparts．AndexpressedforSox一9inboth．Conclusion：Mesenehymalchondrosarcomaisrare，high—gradema—lignancyofboneorsofttissuewithaunique，bimorphicappearanceandpoorprognosis．【Keywords】boneneoplasm；mesenchymalchondrosarcoma；cli

7、nicopathology；differentialdiagnosisModernOncology2014，22(07)：1669—1673【摘要】目的：探讨间叶性软骨肉瘤(mesenchymalchondrosarcoma，MC)的临床病理特征、诊断与鉴别诊断。方法：结合临床资料及影像学所见，分析3例MC患者的组织病理特点并复习相关文献。结果：患者均为成人，平均年龄42．3岁。主要临床表现为疼痛、肿胀、局部