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1、HerpesZosterDefinitionHerpeszosteriscausedbyVaricella-Zostervirus(VZV),classicallyoccursunilaterallywithinthedistributionofasensorynerve,beingcharacterizedbyclusteredvesiclesandconsiderableneuralgia.PathogenandPathogenesisPathogenVaricella-Zostervirus(VZV)ischaracteri
2、zedbyneurotropismanddermatotropism.PathogenesisVZVcausesvaricellainchildhood,andestablisheslatencyinsensorygangliaaftertheprimaryinfection.VZVmayreplicatelaterinlife,takingadvantageofthedeclineinimmunefunction,travelingdownthesensorynerveintotheskin,showingneuralgiaan
3、dclusteredvesicles.ClinicalmanifestationsProdrome:headacheandfeverhyperaesthesiapainintheaffectedarea.FeaturesoflesionsTheeruptionpresentsaspapulesanderythemainthedermatome.Overafewdays,cropsofclusteredredpapulesforminadiscontinuousbandandquicklyevolvetoclearvesicless
4、urroundedbyerythema.Theeruptionmayhavefewlesionsorreachtotalconfluenceinthedermatome.Lesionsmaybecomehemorrhagic,necrotic,orbullous.Thevesiclesslowlybecomepustulars,andrupturetoformcrusts,whichseparateintwotofourweeks,oftenwithscarring.Theregionallymphnodesareenlarged
5、andtender.ComplicationsPostherpeticneuralgia(PHN)Thepainpersistsaftertheskinlesionshavehealed,withthesamequalityasthatofacutezosterpain.>amonthOphthalmicZosterOcularinvolvementismostcommonlyintheformofuveitisandkeratitis.RamsayHuntsyndromeResultsfrominvolvementofthefa
6、cialandauditorynervesbytheVZV.Thepresentingfeaturesinclude:herpesauricularis,facialparalysis,andauditorysymptoms.VZV.Herpeticinflammationofthegeniculateganglionisfelttobethecauseofthissyndrome.Thepresentingfeaturesinclude:herpesauricularis,facialparalysis,andauditorys
7、ymptoms.IncompleteherpeszosterTherearemayonlyneuralgiaandpapuloidlesionsbutwithnoblisters.DisseminatedHerpesZosterAgeneralizedvaricelliformeruptionaccompanyingthesegmentaleruption.Ithasbeendefinedasmorethan20lesionsoutsidetheaffecteddermatome.Itoccurschieflyinoldordeb
8、ilitatedindividuals,especiallyinpatientswithmalignancyandAIDS.DiagnosisandMisdiagnosisDiagnosisTypicallesions:cropsofcluster
