子痫前期患者胎盘组织中pdgfa的表达及意义

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1、子痫前期患者胎盘组织中PDGFA的表达及意义作者：高学印,薛瑞敏,郑秀玲,郭影,吉增良单位：055250河北省巨鹿县医院妇产科(高学印、薛瑞敏、郑秀玲、吉增良);河北医科大学第三医院妇产科(郭影)【摘要】目的通过观察子痫前期患者胎盘组织血小板源性生长因子A(PDGFA)的表达，探讨子痫前期发病机制。方法采用HE染色观察胎盘形态学病理变化，免疫组化法测定39例子痫前期患者及20例正常晚孕妇女胎盘组织中PDGFA的表达强度。结果(1)HE染色显示正常孕足月胎盘绒毛和轻度子痫前期胎盘绒毛中滋养细胞以合体滋养细胞为主，而重度子痫前期胎盘绒毛中细胞滋养细胞明显增生

2、，绒毛大部分不成熟，胎盘蜕膜间质细胞呈大小不等块状、杆状，蜕膜血管内皮细胞纤维化，蜕膜纤维素性坏死也明显增多。(2)重度子痫前期组PDGFA表达强度较正常妊娠组、轻度子痫前期组明显升高(P<0.05)，而PDGFA表达强度在正常妊娠组、轻度子痫前期组差异无统计学意义(P>0.05)。结论重度子痫前期患者胎盘形态学病理变化明显，且与病情严重程度呈平行关系。PDGFA由胎盘产生，并参与了妊娠期高血压疾病的病理生理过程。【关键词】妊娠期高血压疾病;血小板源性生长因子A;胎盘组织ExpressionandsignificanceofPDGFAinp

3、lacentafrompatientswithpre-eclampsiaGAOXueyin,XUERuimin,ZHENGXiuling,etal.DepartmentofGynecologyandObstetrics,JuluCuntryHospital,Hebei,Julu055250,China【Abstract】ObjectiveToobservethechangesofplateletderivedgrowthfactor(PDGFA)inpatientswithpreeclampsiatoexploreitspathogenesis.Metho

4、dsTheexpressionlevelsofPDGFAinplacentaof39patientswithpreeclampsiaand20normallatepregnantwomenweredetectedbyimmunohistochemstryandHEstaining.Results(1)Theplacentalvillusincontrolgroupandmildpreeclampsiagroupwerecharacterizedbydominantsyneytiotrophoblastcells,however,theplacentalvi

5、lllusinseverepreeclampsiagroupwerecharacterizedbycytotrophoblasticcellsproliferating,basementmembranethickening,syncytiotrophoblastknottingincreasing,synchtiotrophoblastbudding.(2)ThepositiveexpressionratesofPDGFAincontrolgroup,mildpreeclampsiagroupandseverepreeclampsiagroupwere3

6、8.89%,44.97%and76.54%respectively.Therewasasignificantdifferencebetweenmildandseverepreeclampsiagroup(P<0.05),buttherewasnodifferencebetweencontrolgroupandmildpreeclampsiagroup(P>0.05).ConclusionThepathologicalchangesofplacentaareparalleledwiththeseverityofpreeclampsia，whic

7、hindicatesthattheplacentalpathologicalchangesplayanimportantroleinthedevelopmentofseverepreeclampsia.TheexpressionofPDGFAmaybeinvolvedinthepathophysiologicalprocessofhypertensioningestationalperiod.【Keywords】hypertensioningestationalperiod;plateletderivedgrowthfactorA;placenta妊娠期

8、高血压疾病(hypert