肿瘤来源外泌体对宿主免疫状态的影响

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1、授予单位代码10089学号或申请号20153474中国图书分类号R730.5HebeiMedicalUniversity硕士学位论文专业学位肿瘤来源外泌体对宿主免疫状态的影响研究生：成士超导师：李中信教授专业：外科学二级学院：第四医院2018年3月目录中文摘要············································································································1英文摘要·································

2、···········································································2英文缩写············································································································3综述肿瘤来源外泌体对宿主免疫状态的影响··········································4致谢·······················

3、···························································································19个人简历··········································································································20中文摘要肿瘤来源外泌体对宿主免疫状态的影响摘要外泌体是由活细胞分泌的一种囊泡状结构，内含有母体细胞来源的蛋白质、miRNA、mRNA等多种成分

4、，参与细胞间物质交换和信息交流。肿瘤来源的外泌体可通过多种机制影响宿主的免疫状态，导致肿瘤发生免疫逃逸。本文重点阐述肿瘤来源外泌体对多种免疫细胞的调节作用，包括影响NK细胞的杀伤活性、促进巨噬细胞极化、抑制T细胞增殖、诱导免疫抑制性细胞分化等，旨在深化对肿瘤与免疫之间相互作用的认识，寻求新的免疫治疗靶点。关键词：外泌体，肿瘤，免疫细胞，免疫逃逸，免疫治疗1英文摘要TheEffectofTumor-derivedExosomesonImmuneStateoftheHostABSTRACTExosomesareakindofvesicularstru

5、cturesecretedbylivingcells,whichcontainproteins,miRNA,mRNAandothercomponentsderivedfrommatermalcells.Exosomesareimportantmediaforintercellularmaterialexchangeandinformationtransduction.Tumor-derivedexosomescanaffecttheimmunestateofthehostthroughmultiplemechanisms,resultingini

6、mmuneescapeofthetumor.Thepresentstudyfocusesontheregulationoftumor-derivedexosomesonavarietyofimmunecells,includingeffectsonthekillingactivityofNKcells,promotionofmacrophagepolarization,inhibitionofTcellproliferation,inductionofimmunosuppressivecelldifferentiationetc.Weaimtod

7、eepentheunderstandingoftheinteractionbetweentumorandimmunityandtoexplorenovelimmunotherapeutictargets.Keywords:Exosomes,Tumor,Immunocyte,Immuneescape,Immunotherapy2英文缩写英文缩写英文缩写英文全称中文全称NKNaturalkillercell自然杀伤细胞MHCMajorhistocompatibilitycomplex主要组织相容性复合体TLR2Toll-likereceptor2To

8、ll样受体2MDSCMyeloid-derivedsuppressorcells骨髄来源的抑制性细胞DCDendriticcell树突状