脑小血管病非痴呆患者脑微出血cmbs数量、部位与认知功能损害的相关性分析

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1、脑小□躺廠课患者脑微出二CMBs数量.部位与认2018-04-0809:50:18中国现代医生2018年4期武建朝［摘耍］戸的分析脑小血管病非痴呆患者脑微出血(CMBS)数量、部位与认知功能损害的相关性。方法随机选择2016年6月〜2017年6月来我院进行脑小血管病检查的患者120例进行临床研究。根据患者MRI检查结果确定CMBs的数量和部位，对所有患者认知功能损害情况进行评价。结果120例患者检测后有427枚CMBs,其中基底节CMBs有91枚占21.31%,其次为颍叶和额叶，分别为65枚、50枚，占15.22%、11.71%oMoCA评分-26

2、患者CMBs数量低于MoCA评分<26,差异有统计学意义(PvO.05)。CSVD患者MoCA总分、记忆力与CMBs数量有负相关(P<0.05)。视空间执行与额叶CMBs,语言、定向与枕叶CMBs,注意力与岛叶、DPWM.基底节CMBs,MoCA总分与DPWM部位CMBs,记忆与DPWM部位CMBs,语言与DPWM部位CMBs呈负相关(P<0.05)o结论脑小血管病非痴呆患者的脑微出血部位和数量，与认知功能损害具有密切关联。［关键词］脑小血管病；脑微出血；认知功能；脑白质病变［中图分类号］R743.3［文献标识码］B［文章编号］1673-9701(

3、2018)04-0051-03［Abstract］ObjectiveToanalyzethecorrelationbetweenthenumberandlocationofcerebralmicrohaemorrhage(CMBs)andtheimpairmentofcognitivefunctioninnondementiapatientswithsmallcerebralvasculardisease.MethodsAtotalof120patientswithcerebralmicrovasculardiseasefromJune2016to

4、June2017yearsfromJunetoourhospitalwererandomlyselectedtocarryoutclinicalstudy.ThenumberandlocationofCMBsweredeterminedaccordingtotheresultsofthepatient'sMRIexamination,andthecognitiveimpairmentofallpatientswasevaluated・Results120patientshad427CMBsafterdetection,ofwhich91oftheb

5、asalgangliawereCMBs,accountingfor21.31%,followedbytemporallobeandfrontallobe,65and50,respectively,accountingfor15.22%and11.71%.ThenumberofpatientswithCMBsMoCAscoreover26waslowerthanthatofMoCAscoreof<26,thereweresignificantdifferences(P<0.05)・Therewasanegativecorrelationbetween

6、thetotalscoreofMoCA,memoryandthenumberofCMBsinCSVDpatients(P<0.05).VisualspatialexecutionisnegativelyrelatedtofrontallobeCMBs,Ianguage,orientationandoccipitallobeCMBs.Attentionwasnegativelycorrelatedwiththetotalscoreofinsula,DPWM,basalgangliaCMBs,MoCAandDPWMlocationCMBs,memory

7、andDPWMlocationCMBs,andlanguageandDPWMsiteCMBs(CMBs)(P<0.05)・ConclusionThelocationandnumberofcerebralmicrohaemorrhageinnondementiapatientswithsmallcerebralvasculardiseasearecloselyrelatedtotheimpairmentofcognitivefunction.［Keywords］Cerebralmicrovasculardisease；Cerebralmicrohem

8、orrhage：Cognitivefunction：Whitematterlesionofthebrain脑小血管病(CS