可降解心房隔膜缺损、卵圆孔未闭(asd%2fpfo)封堵器材料的合成与性能研究

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1、万方数据青岛科技大学研究生学位论文SYNTHESISANDPROPERTIESOFDEGRADABLECOPOLYⅣ匝RSASATRIALSEPTALDEFECTANDPATENTFORAMENOVALEOCCLUDERMATERIALABSTRACTHeartoccluderconstitutesarewidelyusedinthetreatmentofcongenitalheartdisease．TheconventionalNiTialloyoccluderisnon·degradable，andcouldinduceaseries

2、ofcomplicationssuchasblockofconduction，Arrhythmia，erosion,thrombosis，residualshunt，hemolysis，nickelallergy,etc．Thedevelopmentofbiodegradableoccluderwithgoodmechanicalpropertiesandappropriatedegradationratehasgraduallybecomeahotresearchareaforinterventiontherapyofcongenita

3、lheartdisease．Itisalsothetopicofthiswork．(1)Variousreactionconditionswereusedtosynthesizehighmolecularweightpoly(trilethylenecarbonate-co-L-lactide-eO-glycolide)(PTLGA)terpolymers．Datashowthattheoptimalconditionsareasfollows：moleratioofmonomerstocatalyst8000／1，temperature

4、140oC，andmonomersfeedratioTMC／LLA／GA=25／60／15．Undertheseconditions，themolecularweightofPTLGAreached135900．(2)AseriesofhighmolecularweightPTLGAterpolymers谢mdifferentcompositionswerepreparedusingstannousoctoate(Sn(Oct)2)asthecatalyst．Polymerswerecharacterizedbygelpermeation

5、chromatography(GPC)，ini}aredspectroscopy(FTIR)，1Hnuclearmagneticresonance(1HNMR)，differentialscanningcalorimeter(Dsc)andthermo-gravimetricanalysis(TGA)．Filmsampleswerepreparedbysolutioncastingmethod．Tensiletests，invitrodegradation，biocompatibilitystudieswerecarriedout．(3)

6、ThePTLGAterpolymersexhibitlowertensilestrengthascomparedtolit万方数据poly(L—lactide)(PLLA)duetoincorporationoftheacontentsofTMCandGA．Incontrast，thetoughnessoftheterpolymersisgreatlyimproved．Thustheycanbeusedaspotentialmaterialforheartoccluderfabrication．(4)Invitrodegradationo

7、fterpolymerPTLGA25／60／15wasstudiedincomparisonwithacopolymerPTLA25／60．TheterpolymerdegradesfasterthanwithPTLA25／60duetothepresenceoffastdegrdingGAcomponent．Morphologicalchangeswithcrystallizationofdegradationby-productsareobservedinthecaseofPTLA25／60duetoMndecreaseduringd

8、egradationandthestrongerimpactofplasticizationofwaterduringthedegradation．PTLGA25／60／15remainsam