健脾安肠汤治疗腹泻型肠易激综合征的临床研究

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1、提要目的：本研究是为了观察健脾安肠汤治疗腹泻型肠易激综合征（irritablebowelsyndrome，IBS），中医辨证为肝郁脾虚型泄泻的临床疗效，并从理论和临床研究两个方面探讨其治疗腹泻型IBS的疗效机制，客观评价其有效性和安全性。方法：临床选择符合纳入标准的60例IBS患者，按照就诊的先后顺序随机分为试验组和对照组，其中试验组30例，给予健脾安肠汤治疗，对照组30例，给予得舒特治疗，疗程4周。对治疗后临床主要症状的改善，治疗后、用药3月后的综合疗效、中医证候积分，复发率等指标进行观察比较。结果：临床研究显示：①试验组与对照组的综合疗效、中医证候总疗效，三月后的综合疗效比较有显著性

2、差异；②试验组在消除或改善泄泻、胸胁胀闷、食欲不振、脘腹痞满、抑郁或烦躁，乏力和神疲懒言等症状方面的疗效优于对照组；③对照组复发率明显高于试验组，说明健脾安肠汤在根治IBS腹泻型上更有优势。结论：健脾安肠汤可以有效地改善腹泻型IBS患者的临床症状，并能有效减少愈后复发。在用药过程中未发现有心、肝，肾等重要器官的损害。说明健脾安肠汤是一疗效确切，安全无明显不良反应的治疗腹泻型IBS的中药制剂。关键词健脾安肠汤；腹泻型IBS；肝郁脾虚；临床研究；中医药治疗TheclinicalresearchofJianPiAnChangdecoctioninthetreatmentofirritableb

3、owelsyndrometypediarrhea.Speciality:InternalmedicineoftraditionalChinesemedicineAuthor:DuanXiaodongTutor:LiuWeimingAbstractObjectives:ToobserveJianPiAnChangdecoctioninthetreatmentofchronicdiarrheaofStomachtypediarrhea---irritablebowelsyndrometypediarrhea.TheSpleendeficiencystomachtypefortheclinic

4、alcurativeeffectofdiarrhea,andfromthetwoaspectsoftheoryandclinicalresearchintoJianPiAnChangdecoctionintheirritablebowelsyndrometypediarrhea,theeffectivenessandsafety.Theguidanceofitintheclinicalapplication.Methods:Thisresearchwasbasedon60casesofirritablebowelsyndrometypediarrhea.Spleendeficiencyf

5、romtheclinicofthehospitaltoTCMofjinan.Dividedthemrandomlyintotwogroups.Onegroupwasthetreatmentgroup,30patientsweretreatedwithJianPiAnChangdecoction.Andtheothergroupwasthecontrolgroup,with30patientsbeingtreatedwithDeshute.AllthepatientsmettheTCMdiagnosiscriterion.Boththetwogroupsweretreatedforfour

6、weeks.ComparetheeffectiveandtheTCMsyndromeintegralsaftertreatment,forthreemonthsaftertreatmentandtherecurrencerate.Results:ThetreatmentgroupisbetterthanthecontrolgroupintheTCMsyndromeintegralevaluationaftertreatmentandthreemonthsaftersuccedenttreatment.Thecomprehensivecurativeeffectoftreatmentisb

7、etterthanthatofthecontrolgroup.Thetreatmentgrouptoeliminateorimprovereliefindiarrhea,chesttightnessintheexpansionthreat,anorexia,abdominaloftenfull,depressionoranxiousnew,exhaustionandgodexhaustingthesymptomsuchaslazyt