资源描述：
《替米沙坦对六分之五的切除肾脏的大鼠的肾保护作用》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、PaperRenoprotectiveeffectsoftelmisartaninthe5/6nephrectomisedrats†#§^IchiroTsunenari,*TsuyoshiOhmura,RandolphSeidler,MotohikoChachin,ToshihiroHayashi,¥++‡AyakoKonomi,TakehisaMatsumaru,*ToshiyukiSumida,NaoyukiHayashi,YoshiharuHorieKeywords:Abstractpharmacologicalpropertiesoftelmisartan,fibrosis,Thepu
2、rposeofthisstudywastoinvestigatetheclinicalstudieshavebeenconductedtoevaluatevessel,kidney,renoprotectiveeffectoftelmisartanonthetheclinicaleffectivenessandsafetyoftelmisartanangiotensin,advancedstagesofnephropathyinratswithondiabeticnephropathyinpatientswithtype2TGF-β5/6nephrectomy(5/6Nx).Telmisart
3、anwasorallydiabetes.Ithasbeenreportedthattelmisartan*Pharmacokineticsandadministeredfor12weekstoratsthatpreviouslyarrestedprogressiverenaldysfunctioninNon-ClinicalSafetyunderwent5/6Nxorshamoperations.Afterhypertensivepatientswithearly-stagediabeticDepartment,Kawanishicompletionoftheadministrationper
4、iod,thenephropathy.7Makinoetal.8reportedthePharmaResearchInstitute,NippondegreeofrenalinjurywasexaminedeffectivenessofthisdrugtherapyinsuppressingBoehringerIngelheimhistopathologicallyusingindicesoftheprogressionofnephropathyintype2diabeticCo.,Ltd.,3-10-1Yato,Kawanishi,Japan.glomerulosclerosisandles
5、ionsoftherenaltubulepatientswithorwithouthypertension,withoutandinterstitium.Animmunohistochemicalserioussafetyconcerns.RemuzziandRemuzzi9†ProjectCoordinationreviewedthepotentialprotectiveeffectsofstainingfortransforminggrowthfactor–betaGroup,KawanishiPharmaResearch(TGF-β1)wasalsoperformed.telmisart
6、anonrenalfunctiondeteriorationandInstitute,NipponThesuppressionofurinaryproteinwassuggestedthattelmisartanmayeffectivelyBoehringerIngelheimstatisticallysignificantinsurvivinganimalsdosedamelioraterenaldysfunctioninpatientsaffectedCo.,Ltd.,3-10-1Yato,Kawanishi,Japan.withtelmisartan.Theenalaprilgroup’
7、surinarybythemetabolicsyndrome.Inaddition,proteinwasalsosignificantlysuppressedfortelmisartanalsoshowedrenoprotectiveeffectsin#Corporatethesesameparametersinsurvivinganimals.someanimalmodels:spontaneo
