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1、www.elsevier.com/locate/ynimgNeuroImage29(2006)545–556Neuralcorrelatesofadjunctiverivastigminetreatmenttoantipsychoticsinschizophrenia:Arandomized,placebo-controlled,double-blindfMRIstudyVeenaKumari,a,*IngridAasen,a,bDominicffytche,ccdStevenC.R.Williams,andTonmoySharmaaDepartment
2、ofPsychology,InstituteofPsychiatry,King’sCollegeLondon,London,UKbDivisionofPsychologicalMedicine,InstituteofPsychiatry,King’sCollegeLondon,London,UKcCentreforNeuroimagingSciences,InstituteofPsychiatry,King’sCollegeLondon,London,UKdClinicalNeuroscienceResearchCentre,Dartford,UKRec
3、eived12April2005;revised9July2005;accepted1August2005Availableonline21September2005FacilitationofcentralcholinergicactivitymayformapotentialIntroductiontreatmentstrategyforcognitiveimpairmentinschizophrenia.Inarandomized,placebo-controlled,double-blind,parallel-groupdesign,Indivi
4、dualswithschizophreniadisplaymultifacetedcognitiveweinvestigatedtheneuralcorrelatesofcognitiveeffectsofrivastig-impairment(review,Rund,1998)regardlessofachangeintheirmine,anacetylcholinesteraseinhibitor,givenasanadd-ontherapytosymptomstate(Hughesetal.,2003).Thelevelofcognitiveimp
5、air-antipsychotic-treatedschizophreniapatients.Thirty-sixchronicschiz-mentisfoundtopredictthefunctionaloutcomeoftheillnessmoreophreniapatientswithmildcognitiveimpairmenttookpart.After1stronglythantheseverityofpositiveornegativesymptoms(Green,weekonplacebo(baseline),allpatientsent
6、eredadouble-blindprotocol;18wereallocatedtoreceiverivastigmineand18placebo1996;Velliganetal.,1997;AddingtonandAddington,1999;Evansforthenext12weeks(finalsamplewithusableimagingdata:11etal.,2003).Anurgentneed,therefore,hasbeenfeltinrecentyearspatientsonrivastigmine,10onplacebo).Al
7、lpatientsunderwenttofindnoveltreatmentapproachesspecificallytargetingcognitivefunctionalmagneticresonanceimagingduringaparametricFn-back_deficitsinthispopulation(SharmaandHarvey,2000;Harveyetal.,task,involvingmonitoringofdotsinparticularlocationsonascreenat2004).Onesuggestedappro
8、achhasbeentouseacetylcholinesteraseagive
