药学专业英语 药学专业英语(1)

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1、药学专业英语药学专业英语(1)导读：就爱阅读网友为您分享以下“药学专业英语(1)”资讯，希望对您有所帮助，感谢您对92to.com的支持!25.EffectsofExenatideonSystolicBloodPressureinSubjectswithType2Diabetes.Background:Themajorityofpatientswithtype2diabetesmellitushavebloodpressure(BP)exceedingtherecommendedvalueof<1

2、30/80mmHg.Optimalcontrolofhyperglycemiaandhypertensionhasbeenshowntoreducetheincidenceofmacrovascularandmicrovascularcomplicationsduetodiabetes.TreatmentwiththeGLP-1receptoragonistexenatide,previouslydemonstratedtoreducehemoglobinA(1C)andweightinsubjects

3、withtype2diabetes,wasassociatedwithBPreductioninseveralstudies.3。Methods:Thisanalysisexploredtheeffectsofexenatidevs.placeboorinsulinonBPmeasurementsinpooleddatafromsixtrialsincluding2171subjectsstudiedforatleast6months.Results:Overall,6mothsofexenatidet

4、reatmentwasassociatedwithasignificantlygreaterreductioninsystolicBP(SBP)comparedwithplacebo(leastsquaresmean(s.e.):differenceof-2.8mmHg(0.75):P=0.0002)orinsulin(differenceof-3.7mmHg(0.85);P<0.0001),NosignificantintergroupdifferencesindiastolicBP(DBP)w

5、ereobserved.ThemajorityoftheintergroupdifferencewasobservedinsubjectswithSBP>/=130mmHg(differenceof-3.8mmHg(1.08)fromplacebo:P=0.0004;differenceof-4.0mmHg(1.01)frominsulin;P<0.0001).Thelargestintertreatmentdifferencesbetweenexenatideandcomparatorsw

6、ereobservedinsubjectswithSBP>/=150mmHg.SimilarresponseswereobservedinAfrican-Americansubjects.AweakcorrelationbetweentheamountofweightlostandreductioninSBPwasfound(r=0.09,P=0.002)for3exenatide-treatedsubjects.。Conclusions:Theseresultssupporttheneedfor

7、aprospective,randomized,controlledstudyofBPchangesduringexenatidetreatmentinpatientswithhypertensionandtype2diabetes.。百度搜索“就爱阅读”,专业资料,生活学习,尽在就爱阅读网92to.com,您的在线图书馆3