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1、AdvancedDrugDeliveryReviews64(2012)1189–1204ContentslistsavailableatSciVerseScienceDirectAdvancedDrugDeliveryReviewsjournalhomepage:www.elsevier.com/locate/addrTargetingpolymertherapeuticstobone☆aa,b,⁎StewartA.Low,JindřichKopečekaDepartmentofBioengineering,UniversityofUtah,SaltLakeCit
2、y,UT84112,USAbDepartmentofPharmaceuticsandPharmaceuticalChemistry,UniversityofUtah,SaltLakeCity,UT84112,USAarticleinfoabstractArticlehistory:AnagingpopulationinthedevelopingworldhasledtoanincreaseinmusculoskeletaldiseasessuchasReceived6October2011osteoporosisandbonemetastases.Leftuntr
3、eatedmanybonediseasescausedebilitatingpainandintheAccepted18January2012caseofcancer,death.ManypotentialdrugsareeffectiveintreatingdiseasesbutresultinsideeffectspreventingAvailableonline28January2012theirefficacyintheclinic.Bone,however,providesauniqueenvironmentofinorganicsolids,whichc
4、anbeexploitedinordertoeffectivelytargetdrugstodiseasedtissue.ByintegrationofbonetargetingmoietiestoKeywords:drug-carryingwater-solublepolymers,thepayloadtodiseasedareacanbeincreasedwhilesideeffectsde-Bone-targetingDrugdeliverycreased.Therealizationofclinicallyrelevantbonetargetedpolym
5、ertherapeuticsdependson(1)understandingCathepsinKbonetargetingmoietyinteractions,(2)developmentofcontrolleddrugdeliverysystems,aswellas(3)under-HPMAcopolymerstandingdruginteractions.ThelattermakesitpossibletodevelopbonetargetedsynergisticdrugdeliveryPLGAcopolymersystems.Hydroxyapatite
6、©2012ElsevierB.V.Allrightsreserved.Poly(ethyleneglycol)(PEG)ProstaglandinStatinsPTH1–34OsteoporosisBonemetastasisRheumatoidarthritisBonefractureContents1.Introduction..............................................................11902.Targeting..........................................
7、.....................11902.1.Tetracycline...........................................................11912.2.Bisphosphonates........................................................11912.3.Acidicoligopeptides(AO)....................................................11922.4.Estradiolanalog
8、s....
