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1、LPass内毒素外毒素的主要区别？ExotoxinEndotoxinExcretedbylivingcells,mainlybyG+bacteriaIntegralpartofG-bacteriacellwall,liberateduponbacteriadisintegrationpolypeptideLPS,maintoxicpart-lipidAHeat-unstableHeat-stable,160°C?2〜4hrdestroyStrongantigenicity,inducebodytoproduceantitoxin,exotoxin->toxoidWeakantigenic
2、ity,can'tconvertintotoxiodHighlytoxicWeaklytoxicHighselectionfortissues:neurotoxin,cytotoxin,enterotoxinNon-specific,allendotoxinsproducethesamesymptoms一fever;leukopenia;endotoxemiaandshock;DIC.Structure:Asubunit-Bsubunit.Asubunit:toxicpart;Bsubunit:non-toxic,bindreceptorofsensitivecellLPS:lipidA
3、,corepolysaccharide,specificpolysaccharide(Oantigen)2・Passmechanismofcholerapathogenic:霍舌ITransmission:pollutedwaterandfood，bymouth1)pathogenicfactor:flagellum:motility,;coregulatedpili;:adherence;zonaoccludens:exotoxid;siderophore:captureIron。choleraenterotoxin:containAandBsubunits・Asubunit-Agwe
4、ak,activeunit,entersthecell,stimulatesadenylatecyclase-cAMP
5、・secretingeflectt-severediarrhea;Bsubunit-Aghigh,boundunit,attachestoGM1gangliosidereceptoronepithelialcellsofsmallintestine.2)mechanism:Organisms-oralroute(contaminatedwater,fbod)-stomach-attachtothesmallintestineepithelialcells(non・pen
6、etration)-multiplication-choleraenterotoxin・adenylatecyclase-cAMPconcentration—secretingeffect^-severediarrhea(rice-waterstools)-rapiddehydrationandhypovolemicshock低血容量休克・diein12〜24hours.临床特点:patientsmayloseasmuchas10〜15litersofliquid/dayRapiddehydration:metabolicacidosis;andhypovolemiashock低血容量性
7、休克；renalfailure;-deathRice-waterstoolsPreventionandtreatment:vaccine:dead-bacterialvaccine;liveattenuatedoralvaccines・Sanitationimprove:Improvedfoodhandlingoreplacementoffluidandelectrolytes电角军质Antibiotics:(tetrocyclines)3・PassClostridiumtetanipathozenesis破伤风Regionalanaerobiccondition:l.Deep,narr
8、owwoundcontaminatedbysoil;2.Necrotic坏死的tissue;3.Companiedwithaerobeorfacultativeanaerobeinfection.2)pathogenicsubstance:Tetanospasmin破伤风痉挛毒素・neurotoxin:proteinTetanolysin破伤风溶血毒素3)mcchanism:根据课件整理一下Spores-vegetativebact
