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ID:42268756
大小:968.12 KB
页数:30页
时间:2019-09-10
《狼疮性肾炎肾活检病理评分和临床评分相关研究》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中国医科大学硕士学位论文狼疮性肾炎肾活检病理评分和临床评分相关研究姓名:刘强申请学位级别:硕士专业:内科学指导教师:王力宁201103·中文结构式摘要·狼疮性肾炎肾活检病理评分和临床评分相关研究目的探讨狼疮性肾炎(LN)病理评分与临床评分的相关性,试图依据临床评分系统预测和评估其肾脏病理活动性,同时比较4种临床评分系统。方法回顾性分析了125例狼疮性肾炎肾活检患者的病例资料,根据国际肾脏病协会/肾脏病理学会(ISN/RPS)2003LN分型标准进行病理分型,并分别进行活动性指数(AI)、慢性指数(CI)评分,肾小管间质
2、病变(TIL)评分,同时应用系统性红斑狼疮疾病活动指数2000(SLEDAl2000),英岛狼疮评定组指数2004(BILAG2004),系统性狼疮活动性测定(SL删)及狼疮活动计算标准(LACC)4种临床评分系统判断其临床活动度.与病理评分进行相关性分析。结果l、125例患者中,病理类型以弥漫性(Iv型)最多(53%)。2、LN患者II、III型及Ⅳ型的SLEDAl2000评分,BILAG2004及SLAM评分均与其AI呈正相关(03、04、导临床治疗。关键词狼疮肾炎;肾脏病理;SLEDAl2000评分系统;BILAG2004评分系统;SLAM评分系统;LACC系统评分系统;2·英文结构式摘要·ClinicalstudyofrelationshipbetweenpathologyscoreandfourClinicalscoreinlupusnephritispatientswithrenalbiopsy一-objectiveToexploretherelevanceoftheclinicalscoreandpathologyscoreandassessf5、ourscoringsystemincludingsystemiclupuserythematosusdiseaseactivityindex2000(SLEDAl2000)、BritishIsletLupusAssessmentGroup2004(BILAG2004)、systemiclupusactivitymeasure(SLAM)andlupusactivitycriteriacount(LACC)byanalyzingthebiopsyresultsandrelatedlaboratorytestsonlup6、usnephritis(LN).MethodsRetrospectiveanalyzed125casesofpatients谢threnalbiopsy.AllbiopsiedtissueswerescoredbasedonthetoISN/RPS2003lupusnephritispathologicaltypingstandards,Acuteindex(AI),ChronicIndex(COScore,tubulointerstitiallesions(TIL)Scorewereusedtoevaluatethe7、activitiesoflupusnephritisandSLEDAl2000,BILAG2004,SLAMandLACCwereusedtoevaluatetheclinicaldiseaseactivity.TheadssociationbetweenpathologicalchangesanddiseaseactivitiesWasassessed.ResultsAccordingtOISN/RPS2003pathologicaltypestandard,amongthesepatiemstypeIVwasthe8、mostcommontype,whichaccountedfor53percentofallbiopsiedtissues.②ForthosepatientswithLNtypeII,1II,IV.theirSLEDAI2000score,BILAG2004,SLAMandLACCrenalbiopsyAIWaspositivel
3、04、导临床治疗。关键词狼疮肾炎;肾脏病理;SLEDAl2000评分系统;BILAG2004评分系统;SLAM评分系统;LACC系统评分系统;2·英文结构式摘要·ClinicalstudyofrelationshipbetweenpathologyscoreandfourClinicalscoreinlupusnephritispatientswithrenalbiopsy一-objectiveToexploretherelevanceoftheclinicalscoreandpathologyscoreandassessf5、ourscoringsystemincludingsystemiclupuserythematosusdiseaseactivityindex2000(SLEDAl2000)、BritishIsletLupusAssessmentGroup2004(BILAG2004)、systemiclupusactivitymeasure(SLAM)andlupusactivitycriteriacount(LACC)byanalyzingthebiopsyresultsandrelatedlaboratorytestsonlup6、usnephritis(LN).MethodsRetrospectiveanalyzed125casesofpatients谢threnalbiopsy.AllbiopsiedtissueswerescoredbasedonthetoISN/RPS2003lupusnephritispathologicaltypingstandards,Acuteindex(AI),ChronicIndex(COScore,tubulointerstitiallesions(TIL)Scorewereusedtoevaluatethe7、activitiesoflupusnephritisandSLEDAl2000,BILAG2004,SLAMandLACCwereusedtoevaluatetheclinicaldiseaseactivity.TheadssociationbetweenpathologicalchangesanddiseaseactivitiesWasassessed.ResultsAccordingtOISN/RPS2003pathologicaltypestandard,amongthesepatiemstypeIVwasthe8、mostcommontype,whichaccountedfor53percentofallbiopsiedtissues.②ForthosepatientswithLNtypeII,1II,IV.theirSLEDAI2000score,BILAG2004,SLAMandLACCrenalbiopsyAIWaspositivel
4、导临床治疗。关键词狼疮肾炎;肾脏病理;SLEDAl2000评分系统;BILAG2004评分系统;SLAM评分系统;LACC系统评分系统;2·英文结构式摘要·ClinicalstudyofrelationshipbetweenpathologyscoreandfourClinicalscoreinlupusnephritispatientswithrenalbiopsy一-objectiveToexploretherelevanceoftheclinicalscoreandpathologyscoreandassessf
5、ourscoringsystemincludingsystemiclupuserythematosusdiseaseactivityindex2000(SLEDAl2000)、BritishIsletLupusAssessmentGroup2004(BILAG2004)、systemiclupusactivitymeasure(SLAM)andlupusactivitycriteriacount(LACC)byanalyzingthebiopsyresultsandrelatedlaboratorytestsonlup
6、usnephritis(LN).MethodsRetrospectiveanalyzed125casesofpatients谢threnalbiopsy.AllbiopsiedtissueswerescoredbasedonthetoISN/RPS2003lupusnephritispathologicaltypingstandards,Acuteindex(AI),ChronicIndex(COScore,tubulointerstitiallesions(TIL)Scorewereusedtoevaluatethe
7、activitiesoflupusnephritisandSLEDAl2000,BILAG2004,SLAMandLACCwereusedtoevaluatetheclinicaldiseaseactivity.TheadssociationbetweenpathologicalchangesanddiseaseactivitiesWasassessed.ResultsAccordingtOISN/RPS2003pathologicaltypestandard,amongthesepatiemstypeIVwasthe
8、mostcommontype,whichaccountedfor53percentofallbiopsiedtissues.②ForthosepatientswithLNtypeII,1II,IV.theirSLEDAI2000score,BILAG2004,SLAMandLACCrenalbiopsyAIWaspositivel
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