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1、氟西汀联合阿立哌哩治疗抑郁症对照探究作者：林汉民刘永忠徐娟谢智【摘要】目的探讨氟西汀联合阿立哌哇治疗抑郁症的临床疗效和安全性。方法将81例抑郁症患者随机分为两组,研究组应用氟西汀联合阿立哌吐治疗，对照组单用氟西汀治疗，观察8Wo于治疗前及治疗1w、2w、4w、6w、8w末采用汉密顿抑郁量表、临床总体印象量表评定临床疗效，副反应量表评定不良反应。结果治疗8w末研究组有效率72.5%,对照组50%,研究组显著高于对照组(x2=4.168,P<0.05)o研究组治疗第1w末汉密顿抑郁量表总分、阻滞、睡眠障碍因子分，第2w、4w末总分及阻滞、焦虑、
2、睡眠障碍、认知障碍因子分，第6w、8w末总分及阻滞、焦虑因子分均显著低于对照组(P<0.05或0.01)o治疗后临床总体印象量表病情严重程度、疗效总评、疗效指数因子评分均显著低于对照组(P<0.05)o两组不良反应均轻微，副反应量表评分均无显著性差异(P>0.05)o结论氟西汀联合阿立哌哩治疗抑郁症较单用氟西汀起效快，改善患者的阻滞、焦虑情绪、睡眠、认知障碍更为突出，提高总体疗效更为显著，且未加重不良反应，安全性高、依从性好。【关键词】抑郁症；氟西汀；阿立哌哇；汉密顿抑郁量表；临床总体印象量表；副反应量表[Abstract】Objectiv
3、eToexploretheefficacyandsafetyoffluoxetinecombinedwitharipiprazoleindepession.Methods81depressionpatientswererandomlydividedintoresearchgroupreceivingfluoxetinecombinedwitharipiprazoleandcontrolgroupdoingfluoxetineonlyfor8weeks・ClinicalefficacieswereassessedwiththeHamilton
4、DepressionScale(HAMD)andtheClinicalGlobalImpression(CGI)andadversereactionswiththeTreatmentEmergentSymptomScale(TESS)beforetreatmentandattheendsofthe1st,2nd,4th,6thand8thweektreatmerit.ResuItsAttheendofthe8thweek,effectiveratewas72.5%oftheresearchand50%ofthecontrolgroup,th
5、eformersignificantlyhigherthanthelatter(x2=4.168,P<0.05).TheHAMDtotal,blockageandsomnipathyscoreattheendofthe1stweek,total,blockage,anxiety,somnipathyandcognitivedisorderattheendsofthe2ndand4thandtotai,blockageandanxietyattheendsofthe6thand8thwereallsignificantlylowerinthe
6、researchthaninthecontrolgroup(P<；0.05or0・01).Aftertreatment,scoresofseveritydegreeofpatientscondition,generalcommentandindexofcurativeeffectwereallsignificantlylowerintheresearchthaninthecontrolgroup(P<；0.05)・Adversereactionsofbothgroupsweremildandtherewasnosignificant
7、differenceintheTESSscores(P>；0.05)・ConclusionFluoxetinecombinedwitharipiprazoleactsmorerapidlythanfluoxetineonlyinthetreatmentofdepression,improvespatients，blockage,anxiousemotion,sleepandcognitivehandicapandincreasesglobalcurativeeffectmoreoutstandingly,doesntaggravatea
8、dversereactions,andhashighersafetyandbettercompliance・[Keywords]Depression；fluoxetine；ari
