洛丁新加益气活血汤治疗糖尿病肾病的临床观察.doc

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1、Clinicalobservationoneffectofurineprotein/24h，serumcreatinineandbloodurianitrogenofdiabeticnephropathytreatedbybothyiqihuoxuedecoctionandLotensinMajor:ClinicinternalmedicineofTraditionalChineseMedicinePostgraduate:ZhangLixiaTutor:ChiefPhysicianZhouGuoyingAbstractObjective:Toexplorethee

2、ffectivetherapeuticmethodofcombinationofTCMandwesternmedicinetopostponerenalfunctiondeteriorationofdiabeticnephropathy.Method:AccordingtoWHOdiagnosiscriteriaandTCMdifferentiationcriteria.weselected60cases(29maleand31female),Whichweredividedintotwogroups(AandB)atrandom.Twogroupshavenosi

3、gnificantdifferencebystatisticsinage,sex?urineprotein/24handserumcreatinine.Withcontroldie,sportandhavehypoglycemicdrugorsubcutaneousinjectioninsulintherapytocontrolbloodglucosestrictly,fastingplasmsglucose(FPG)V7.0mmol/L,glycosylatedhemoglobin<8%,AgroupwastreatedbyLotensin(10mg-20mg.Q

4、d)for2months,BgroupswastreatedbybothyiqihuoxuedecoctionandLotensinfor2months,detectedurineprotein/24h,serumcreatinine(SCR)andbloodurianitrogen(BUN),observingmarkerindicatedbymeanandstandarddeviationbeforeandaftertheraphy,contrastedbypairedsampleT-TestorindependentsampleT-Testbetweenbef

5、oreandaftertheraphyfortwogroups・Result:ScrandBUNofAgrouphadnosignificantdifferencethanthoseofBgroup(p>0.05)・urineprotein/24hoftwogroupsdescentedaftertheraphy,whichhassignficancedifferenceinstatistics・BgroupispriortoAgroup.Conclusion:It'sbettertotreatwithcombinationofTCMandwesternmedici

6、nethanonlyACEIinpostponingrenalfunctiondeteriorationofdiabeticnephropathyandprogressinglifequantity.MeSHTerm：diabeticnephropathies/tcmwmtherreinforcingdrugs/theruseblood-activationdrugs/theruseangiotensin-convertingenzymeinhibitors/theruseproteinuria/bloodcreatinine/bloodbloodureanitro

7、gen/blood摘要目的：寻求延缓糖尿病肾病肾功能恶化的中西医结合治疗的有效方法。方法：将60例病例随机分为A组及B组。两组在年龄、性别、24小时尿蛋白定量和血肌酹经统计学处理，未见显著差异。经饮食、运动及降糖药物治疗，有效严格地控制血糖，空腹血糖V7・Ommol/L者，糖基化血红蛋白V8%的情况下。A组为洛汀新治疗对照组，B组为益气活血汤+洛汀新组。治疗时间2个月，检测治疗前后24小时尿蛋白定量、Set及血尿素氮(BUN)水平，观察指标用均数土标准差(元土s)表示，治疗前后用成对t检验及组间对照用t检验。结果：洛汀新组、益气活血汤+洛汀新组治疗前后Ser水平