脑钠肽及和肽素水平与冠心病患者冠脉病变程度的相关性.pdf

《脑钠肽及和肽素水平与冠心病患者冠脉病变程度的相关性.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·145··论著·脑钠肽及和肽素水平与冠心病患者冠脉病变程度的相关性王晓艳，杨侃，孙明，党瑜华【摘要】目的探讨冠心病患者冠状病变程度与脑钠肽(BNP)、和肽素(Copeptin)水平之间的关系。方法检测3O例急性心肌梗死患者(AMI组)、38例不稳定型心绞痛患者(UAP组)、43例稳定型心绞痛患者(SAP组)和25例健康对照者血浆BNP和Copeptin水平，比较4组受检者冠状动脉病变支数、左主干病变程度冠脉Gensini评分与BNP和Copeptin水平的相关性。结果4组受检者BNP和Copeptin水平及Gensini积分间差异均有统计学意义(P<0

2、．05)。其中AMI组、UAP组BNP和Copeptin水平与SAP组和对照组比较，差异均有统计学意义(P<0．05)；且AMI组BNP和Copeptin水平与UAP组比较，差异有统计学意义(P<0．05)。BNP、Copeptin水平与冠脉病变支数、左主干病变程度、冠脉Gensini评分呈正相关(P<0．05)。结论冠心病患者血浆BNP和Copeptin的水平和冠状动脉病变程度之间存在一定关系，可以反映心肌受损的程度，具有重要的临床意义。【关键词】冠心病；脑钠肽；和肽素；心绞痛；心肌梗死【中图分类号】R541．4【文献标识码】A【文章编号】1007—9

3、572(2010)01—0145—03CorrelationofCoronaryArteryStenosiswithPlasmaBrainNatriureticPeptideandCopeptininPatientsⅥthCoronaryHeartDiseasesWANGXiao—yan，YANGKan，SUNMing，eta1．DepartmentofCardiology，ThirdAffiliatedHospital，Cen—tralSouthUniversity，Changsha410013，China【Abstract】ObjectiveTost

4、udythecorrelationofcoronaryarterystenosis(CAS)withplasmabrainnatriureticpep—tide(BNP)andC—terminalportionofpro—vasopressin(Copeptin)inpatientswithcoronaryheartdiseases(CHD)．MethodsThelevelsofBNPandCopeptinweredeterminedin30patientswithacutemyocardialinfarction(groupAMI)，38withuns

5、ta-bleanginapectoris(groupUAP)，43withstable(groupSAP)and25normalcontrols．Thecorrelationsofthenumberofim—pairedcoronaryarteries(CA)，leftmaincoronarystenosisandGensiniscoresofCAwithlevelsofBNPandCopeptinwerecon-paredbetween4groups．ResultsBNP，CopeptinlevelsandGensiniscoresweresignif

6、icantlyhigheringroupsAMIandUAPthaningroupsSAPandcontrol(P<0．05)，BNPandCopeptinweresignificantlyhigheringroupAMIthaningroupUAP．ThelevelsofBNPandCopeptinwerepositivelycorelatedwithnumberofimpairedCA，leftmaincoronarystenosisandGensiniscoresofCA(P<0．05)．ConclusionThereexistsacertainc

7、orelationbetweentheimpairedcoronaryarteriesandtheplasmalevelsofBNPandCopeptin，whichreflectstheimpairmentofmyocardium．Itisofgreatclinicalsignificance．【Keywords】Coronarydisease；Brainnatriureticpeptide；C—terminalportionofpro—vasopressin；Anginapccto—ris；Myocardialinfarction近年来，心血管疾病的

8、血液生化指标在急性冠脉综合征pro—vasopressin，Copeptin)是