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1、米力农治疗老年人慢性肺心病心衰50例疗效观察【摘要】目的观察米力农对老年人慢性肺心病心衰的疗效，寻求纠止老年人慢性肺心病心衰的合理用药。方法50例患者为米力农治疗纽.，在综合治疗的基础上以米力农首剂负荷量50ug/(kg•min)，缓慢静注10min,再以0.5ug/(kg・min)静滴，时间4h,每日1次,7d为1疗程；48例患者为对照纽.，在综合治疗基础上加多巴酚丁胺20〜40mg+5%葡萄糖250ml,以2.5Ug/(kg・min)静滴,每日1次,7d为1疗程。结果治疗组显效率44%(22/50),有效率52%(26/50),总有效率96%；对照组显效
2、率35.4%(17/48),做率45.8%(22/48),总有效率81.1%。治疗纽疗效明显优于对照纽(PvO.Ol)。结论老年慢性肺心病心衰洋地黄类强心剂不但疗效差，口易导致中毒，选择米力农既发挥止性肌力作用，又可扩张血管减轻心脏负荷，疗效肯定、安全。【关键词】老年人慢性肺心病治疗米力农MilrinonetherapyinheartfailureoftheagedchroniccorpulmonaleWANGYibing,XIAOLi,LIULimin,ZHANGTianmin.DepartmentofRespiratoryMedicine,Affilia
3、tedHospitalofWuhanUnivestyScieneandTechnology,Wuhan43CX)64,China[Abstract]ObjectiveToobservetheeffectofmilrinoneinthetreatmentofheartfailureoftheagedchroniccorpulmonale・MethodsMilrinonegroupwasenrolled(50cases).Onthebasisofcomprehensivetreatment,thefirstloadingdoseofMilrinonewas50&
4、mu;g/(kg.min),followedby0.5μg/(kg.min)IVdriptor4h,oncedaily.Onetherapeuticcoursewas7d.Controlledgroupansistedof48cases,inadditiontocomprehensivetherapy,DobutamineHC120〜40nig+5%glucose250nilwasaddedindosageof2.5μg/(kg.min)IVdrip,oncedailyfor7dasatherapeuticcourse.ResultsInther
5、apeuticgroup,theexcellentlyeffectivecaseswerein22/50cases(44%),thefairlyeffectivecaseswerein26/50cases(52%),thetotalimpororementratewas96%.Incontrolgroup,theexcellentlyeffectivecaseswerein17/48cases(35.4%),thefairlyeffectivecaseswerein22/48cases(45.8%),thetotalimprovementratewas81.
6、1%.Theimprovementrateintherapeuticgroupwassignificantlyhigherthanthatofcontrolgroup,(P<0.01)・ConclusionsThetherapeuticeffectofdigitaliscardiacglycosidesintreatmentofheartfailureoftheagedchroniccorpulmonaleareusuallyunsatisfactoryandsometimesitcanresultindigitalisintoxication.Choice
7、ofMilrinonenotonlyhasthepositiveinotropicofcardiacmuscle,butalsoitcandilatethebloodvesselsinordertolessentheheartload.Milrinoneisasafedrugandithasgoodeffectforheartfailureofcorpulmonale・【Keywords]aged：chroniccorpulmonale；treatment；milrinone米力农(milrinone)是-•种新兴的非洋地黄类的止性肌力药物[1],它的临床疗
8、效已得到充分的肯定，但是萇致室性心律失常、加速基础心
