抵当汤对阿尔茨海默病大鼠学习记忆能力的影响-论文.pdf

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1、·论著·中国当代医药2014年3月第21卷第8期抵当汤对阿尔茨海默病大鼠学习记忆能力的影响王康锋t张立娟：孙西庆师冉1．山东中医药大学附属医院，济南250014；2．山东省中医药研究院，济南250014【摘要】目的观察抵当汤对阿尔茨海默病(AD)大鼠学习记忆能力的影响。方法将40只雄性Wistar大鼠随机分为假手术组、模型组、安理申组和抵当汤组。采用右侧海马一次性注射聚集态AB25—35方法制备AD大鼠模型，造模成功后进行定位航行实验及空间探索实验。之后连续灌胃给药，疗程为8周，用药结束后继续进行Morris水迷宫实验。观察各组大鼠学习记忆能力的改变。结果与模型组比较，各给药组大鼠逃

2、避潜伏期明显缩短(P<0．05或P<0．01)，抵当汤组较安理申组缩短更明显(P<0．05)。同时药后安理申组和抵当汤组大鼠跨台次数较实验前明显增加(P<0．05)，与安理申组相比抵当汤组增加更显著(P<0．05)。结论抵当汤可以改善)大鼠的学习记忆能力。【关键词】抵当汤；阿尔茨海默病；学习记忆【中图分类号】R285．5[文献标识码】A【文章编号】1674-4721(2014)03(b)-0016-03TheeffectofDidangdecoctiononlearningandmemoryabilityofAhheimerdiseaseratsWANGKang-fenglZHANG

3、Li-juan。SUNXi-qing~SHIRan1．AffiliatedHospitalofShandongUniversityofTraditionalChineseMedicine，Jinan250014，China；2．ShandongAcade—myofTraditionalChineseMedicine，Jinan250014，China[Abstract]ObjectiveToobservetheeffectsofDidangdecoctiononlearningandmemoryabilityinratswithAhheimerdisease(AD)．Methods4

4、0maleWistarratswererandomlydividedintopseudooperationgroup，modelgroup，ariceptgroupandDidangdecoctiongroup．ADmodelratsweremadeusingtherighthippocampusone-timeinjectionstateofaggregationofAbeta25—35method．Afterthemodeling，navigationtestandspaceexplorationexperimentswereper—formed，andthencontinuou

5、soraladministrationfor8weeks，afterthemedicationMorriswatermazeexperimentwascon—tinuedtoobservethechangesoflearningandmemoryabilityindifferentgroupsofrats．ResultsComparedwithmodelgroup，theescapelatentperiodofratsineachtreatedgroupwasshoaenedobviously(P<0．05orP<0．01)，itwasmoresignificantlysho~ene

6、dinDidangdecoctiongroupascomparetothatinArieeptgroupfp<0．05)．Atthesametime，afteradministration，thestep—down~equencyofratswassignificantlyincreasedthanbeforetheexperimentinbothAriceptgroupandDidangdecoctiongroupfP<0．05)，anditwasmoresignificantlyincreasedinDidangdecoctiongroupcom—paredwithAricept

7、groupf尸l<0．05)．ConclusionDidangdecoctioncanimprovethelearningandmemoryabilityofratswithAlzheimerdisease．[Keywords]Didangdecoction；Alzheimerdisease；Learningandmemory阿尔茨海默病(Alzheimerdisease，AD)是一种以发病率已高达3％～5％[21，给家庭和社会带来了沉重进行性认知障碍和记