欢迎来到天天文库
浏览记录
ID:55932776
大小:535.61 KB
页数:3页
时间:2020-06-16
《血浆同型半胱氨酸与帕金森病相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·临床探讨·中国现代医生2014年4月第52卷第10期血浆同型半胱氨酸与帕金森病相关性研究邓耀芳黄国敏黄丹丹崔明志黄汉宁苏小钢广东省高州市人民医院神经内科,广东高州525200[摘要1目的通过检测帕金森病(PD)患者及健康人群血浆同型半胱氨酸(Hey)的浓度并进行对比,探讨高同型半胱氨酸与帕金森病的风险相关性。方法收集60例帕金森患者及15例健康人群血清进行同型半胱氨酸浓度检测并进行对比分析,其中帕金森病患者随机分为A组(常规治疗+叶酸及维生素B12治疗组)及B组(常规治疗组)进行治疗,各3O例,C组为健康人群,A、B两组患者治疗前后采用帕金
2、森病症状评分量表(UPDRS)评分并进行分析。结果帕金森病患者(A组与B组)Hey水平高于C组(健康人群),差异具有统计学意义(P<0.05),治疗后A组血清Hcy水平低于B组,差异有统计学意义(0.05);A组和B组UPDRS评分均有改善(均P3、3PlasmahomocysteineandParkinsonSdiseaseDENGYaofangHUANGGuominHUANGDandanCUIMingzhiHUANGHanningSUXiaogangNeurologyDepartment,GaozhouCityPeopleSHospitalinGuangdongProvince,Gaozhou525200,China[Abstract]ObjectiveToinvestigatethecorrelationofhighhomocysteineandtheriskofParkinson4、Sdiseasebycorn—paringtheplasmahomocysteine(Hcy)concentrationsoftheParkinson,sdisease(PD)patientsandhealthypeople.MethodsAtotalof60casesofParkinsonSpatientsand15healthyhumanserumhomocysteinewerestatisticallyaria—lyzed.ParkinsonSdiseasepatientswererandomlydividedintogroupA(co5、nventionaltreatmentcombinewithfolicacidandvitaminB12)andgroupB(conventionaltreatment),30casesineach,groupCforhealthypeople;SymptomsofParkinsonSdiseasewasassessedusingUPDRSscore.ResultsConcentrationofHcyinParkinson'sdiseasepatients(AgroupandBgroup)washigherthanthehealthypeop6、le(Cgroup),thedifferencewasstatisticallysignificant(P<0.05).HcylevelsintheadjuvanttreatmentofpatientswithParkinsonSdiseaseafterfolicacidandVitB12waslessthantheconventionaltreatment,differencewasstatisticallysignificant(尸<0.05).UPDRSscoreingroupAandgroupBwereimproved,groupAw7、asbetterthangroupB(P8、isease,PD)是中老年人1资料与方法常见的缓慢进展的神经系统疾病。是中老年人致残的1.1一般资料主要原因之一。发病机制还不十分清楚,PD的主要病采集2011年
3、3PlasmahomocysteineandParkinsonSdiseaseDENGYaofangHUANGGuominHUANGDandanCUIMingzhiHUANGHanningSUXiaogangNeurologyDepartment,GaozhouCityPeopleSHospitalinGuangdongProvince,Gaozhou525200,China[Abstract]ObjectiveToinvestigatethecorrelationofhighhomocysteineandtheriskofParkinson
4、Sdiseasebycorn—paringtheplasmahomocysteine(Hcy)concentrationsoftheParkinson,sdisease(PD)patientsandhealthypeople.MethodsAtotalof60casesofParkinsonSpatientsand15healthyhumanserumhomocysteinewerestatisticallyaria—lyzed.ParkinsonSdiseasepatientswererandomlydividedintogroupA(co
5、nventionaltreatmentcombinewithfolicacidandvitaminB12)andgroupB(conventionaltreatment),30casesineach,groupCforhealthypeople;SymptomsofParkinsonSdiseasewasassessedusingUPDRSscore.ResultsConcentrationofHcyinParkinson'sdiseasepatients(AgroupandBgroup)washigherthanthehealthypeop
6、le(Cgroup),thedifferencewasstatisticallysignificant(P<0.05).HcylevelsintheadjuvanttreatmentofpatientswithParkinsonSdiseaseafterfolicacidandVitB12waslessthantheconventionaltreatment,differencewasstatisticallysignificant(尸<0.05).UPDRSscoreingroupAandgroupBwereimproved,groupAw
7、asbetterthangroupB(P8、isease,PD)是中老年人1资料与方法常见的缓慢进展的神经系统疾病。是中老年人致残的1.1一般资料主要原因之一。发病机制还不十分清楚,PD的主要病采集2011年
8、isease,PD)是中老年人1资料与方法常见的缓慢进展的神经系统疾病。是中老年人致残的1.1一般资料主要原因之一。发病机制还不十分清楚,PD的主要病采集2011年
此文档下载收益归作者所有